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Related Experiment Video

Updated: Jun 12, 2025

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Atlas Drug-Eluting Coronary Stents Inhibit Neointimal Hyperplasia in Sheep Modeling.

Rasit Dinc1, Halit Yerebakan2

  • 1INVAMED Medical Innovation Institute, Ankara, Turkey.

Acta Cardiologica Sinica
|September 23, 2024
PubMed
Summary

Atlas Drug-eluting Coronary Stents coated with PLGA effectively reduced neointimal hyperplasia. Pharmacokinetic studies confirmed minimal sirolimus release after 28 days, indicating a promising treatment for coronary artery disease restenosis.

Keywords:
Drug-eluting Coronary StentPharmacodynamicsPharmacokinetics

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Area of Science:

  • Cardiovascular Medicine
  • Biomaterials Science
  • Pharmacology

Background:

  • Coronary artery disease (CAD) is a major global health concern.
  • Restenosis after coronary interventions remains a significant clinical challenge.
  • Drug-eluting stents offer a solution for controlled drug delivery to prevent restenosis.

Purpose of the Study:

  • To evaluate the pharmacodynamic and pharmacokinetic properties of Atlas Drug-eluting Coronary Stents.
  • To assess the efficacy of poly (lactic acid-co-glycolic acid) (PLGA) coating in drug delivery.
  • To investigate the potential of these stents in managing CAD restenosis.

Main Methods:

  • Utilized a sheep model with 20 non-atherosclerotic female sheep.
  • Randomly assigned animals into 4 study groups and 1 control group.
  • Implanted Atlas Drug-eluting Coronary Stents and monitored pharmacodynamic and pharmacokinetic parameters.

Main Results:

  • Demonstrated a statistically significant reduction in neointimal hyperplasia post-stent implantation.
  • Observed a statistically significant decrease in sirolimus levels in blood samples over time.
  • Two animals experienced mortality post-implantation; other animals showed no significant adverse effects.

Conclusions:

  • Atlas Drug-eluting Coronary Stents coated with PLGA significantly reduce neointimal hyperplasia.
  • Pharmacokinetic analysis indicated no significant sirolimus release from the stent after 28 days.
  • These findings suggest the potential of PLGA-coated stents for managing CAD restenosis.