Correlation study of multiple inflammatory indices and vertebral compression fracture: A cross-sectional study

Area of Science:

• Osteoporosis Research
• Inflammatory Biomarkers
• Skeletal Health

Background:

• Vertebral compression fractures (VCFs) are common in osteoporosis, a condition influenced by chronic inflammation.
• The precise relationship between inflammatory indices and VCF occurrence requires further elucidation.

Purpose of the Study:

• To assess the correlation between multiple inflammatory indices (NLR, MLR, PLR, SII, SIRI) and VCFs in osteoporosis patients.
• To explore the clinical significance of these inflammatory indices for VCF risk assessment.

Main Methods:

• Retrospective analysis of clinical data from 310 osteoporosis patients.
• Statistical methods included Spearman analysis, binary logistic regression, and ROC curve analysis.
• Evaluation of neutrophil-to-lymphocyte ratio (NLR), monocyte-to-lymphocyte ratio (MLR), platelet-to-lymphocyte ratio (PLR), systemic immune-inflammatory index (SII), and systemic inflammatory response index (SIRI).

Main Results:

• VCFs were present in 43.55% of patients.
• NLR, MLR, SII, and SIRI showed positive correlations with VCF occurrence.
• NLR, MLR, and SIRI were identified as independent risk factors for VCFs, while hip bone mineral density (BMD) was a protective factor.
• MLR demonstrated significant diagnostic efficacy for VCFs (AUC 0.671).

Conclusions:

• Neutrophil-to-lymphocyte ratio (NLR), monocyte-to-lymphocyte ratio (MLR), and systemic inflammatory response index (SIRI) are significant independent risk factors for vertebral compression fractures.
• These inflammatory indices hold potential for clinical application in evaluating VCF risk in osteoporosis patients.