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Predicting biomarkers in laryngeal squamous cell carcinoma based on the cytokine-cytokine receptor interaction pathway

  • 0The Second School of Clinical Medicine of Binzhou Medical University, Yan Tai, China.
Heliyon +

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September 23, 2024

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September 23, 2024

View abstract on PubMed

Summary

This summary is machine-generated.

Bioinformatics identified seven differentially expressed genes in the cytokine-cytokine receptor interaction (CCRI) pathway. Mendelian randomization confirmed cytokine receptors as a risk factor for laryngeal squamous cell carcinoma (LSCC), offering new therapeutic targets.

Area Of Science

  • Oncology
  • Genetics
  • Bioinformatics

Background

  • Laryngeal squamous cell carcinoma (LSCC) is a significant health concern.
  • Identifying molecular pathways and biomarkers is crucial for understanding LSCC pathogenesis.
  • The cytokine-cytokine receptor interaction (CCRI) pathway's role in LSCC requires further investigation.

Purpose Of The Study

  • To identify differentially expressed genes within the CCRI pathway in LSCC.
  • To validate potential biomarkers for LSCC using bioinformatics and Mendelian randomization (MR).
  • To explore the causal relationship between cytokine receptors and LSCC risk.

Main Methods

  • Downloaded and analyzed LSCC-related gene expression datasets from the GEO database.
  • Screened for differentially expressed genes in the CCRI pathway.
  • Performed two-way Mendelian randomization to assess the causal link between cytokine receptors and LSCC.
  • Utilized multiple databases (DGIdb, Miranda, etc.) to analyze gene-drug, gene-immune cell, and gene-RNA interactions.

Main Results

  • Identified seven differentially expressed genes (CD27, CXCL2, CXCL9, INHBA, IL6, CXCL11, TNFRSF17) in the CCRI pathway.
  • MR analysis indicated that CCRI receptors are a risk factor for LSCC (OR = 1.629, P = 0.026).
  • The identified genes showed correlations with drug responses, immune cell infiltration, and RNA interactions.
  • Validation set analysis confirmed the differential gene expression findings.

Conclusions

  • Differential gene expression in the CCRI pathway was identified in LSCC.
  • Mendelian randomization supports cytokine receptors as risk factors for LSCC.
  • These findings offer novel insights into LSCC pathogenesis and potential therapeutic targets.

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