Hormone replacement therapy and risk of pancreatic cancer in postmenopausal women: Evidence from the US National Inpatient Sample 2008-2018
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View abstract on PubMed
Summary
This summary is machine-generated.Hormone replacement therapy (HRT) may reduce pancreatic cancer risk in postmenopausal women. This study found HRT associated with significantly decreased odds of pancreatic cancer, particularly in women aged 55-74.
Area Of Science
- Oncology
- Endocrinology
- Epidemiology
Background
- Pancreatic cancer is an aggressive malignancy with high mortality.
- Previous research on hormone replacement therapy (HRT) and pancreatic cancer risk has produced conflicting results.
- This study investigates the association between HRT and pancreatic cancer risk in postmenopausal women.
Purpose Of The Study
- To determine if HRT use is associated with a reduced risk of pancreatic cancer in postmenopausal women.
- To analyze the association in different age groups and among women with specific health conditions.
Main Methods
- A population-based, retrospective study using data from the US National Inpatient Sample (NIS) from 2008-2018.
- Inclusion criteria: hospitalized females aged 55 years and older.
- Univariate and multivariable regression analyses were performed to assess associations between HRT and pancreatic cancer diagnosis.
Main Results
- The analysis included 35,309 women using HRT and 141,236 women not using HRT, matched by age.
- Multivariable analyses revealed that HRT use was significantly associated with decreased odds of pancreatic cancer (adjusted OR, 0.69).
- Reduced odds of pancreatic cancer were observed in women aged 55-74 using HRT, as well as in non-hypertensive and non-hyperlipidemic groups.
Conclusions
- Hormone replacement therapy (HRT) is associated with a reduced risk of pancreatic cancer in US postmenopausal women.
- The protective association appears stronger in women aged 55-74.
- Further research is warranted to elucidate the underlying biological mechanisms responsible for this observed association.
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