Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Liver Regeneration01:24

Liver Regeneration

3.2K
The liver is an important organ in vertebrates that plays an essential role in metabolism. It is also responsible for storing and redistributing nutrients such as carbohydrates, fats, and vitamins in the body. Additionally, the liver releases bile salts which are critical for digesting food and eliminating toxic metabolites from the body.
Cells of Liver
The liver comprises four major types of cells— hepatocytes, stellate, Kupffer, and sinusoidal endothelial cells. The hepatocytes are...
3.2K
Liver Physiology01:30

Liver Physiology

454
The liver, an essential organ in the human body, performs over 200 vital functions that can be broadly categorized into metabolic, hematological, endocrine regulation, and bile production.
Metabolic Regulation:
The liver is the central organ involved in regulating blood composition. It stabilizes blood glucose levels, maintaining them within the range of  70–110 mg/dL. When these levels drop, the liver breaks down glycogen reserves and releases glucose into the bloodstream. It can...
454
Diseases of the Liver and Gallbladder01:26

Diseases of the Liver and Gallbladder

486
Liver and gallbladder diseases are a significant health concern, with prominent conditions including cirrhosis, hepatitis, non-alcoholic fatty liver disease (NAFLD), and gallstones. Jaundice is a common manifestation of liver and biliary disease.
Cirrhosis is characterized by the scarring of hepatic lobules in the liver, which are replaced by fibrous tissue, affecting the liver's normal functioning. NAFLD, on the other hand, is caused by an excessive build-up of fat in the liver, not...
486

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Awareness, attitudes, and practice intentions toward telemedicine among Egyptian medical students and interns.

BMC medical education·2026
Same author

An Optimized and Improved Protocol for Efficient Isolation of Extracellular RNA from Human Serum.

Current protocols·2026
Same author

Comparative Augmentative Efficacy of Second-Generation Antipsychotics in Adult Treatment-Resistant Depression: A Systematic Review.

Cureus·2026
Same author

Association of Serum Lithium Levels with Insulin Resistance in Type-2 Diabetes Patients.

Biological trace element research·2026
Same author

20/ (fasting C-peptide × fasting plasma glucose) as a novel marker for insulin resistance in obese children and adolescents.

Pediatric research·2026
Same author

Clinically Proven Cardiac Sarcoidosis Presenting as Recurrent Ventricular Tachycardia With Severely Reduced Left Ventricular Function: A Case Report.

Cureus·2026

Related Experiment Video

Updated: Jun 12, 2025

Generation of a Rat Model of Acute Liver Failure by Combining 70% Partial Hepatectomy and Acetaminophen
09:44

Generation of a Rat Model of Acute Liver Failure by Combining 70% Partial Hepatectomy and Acetaminophen

Published on: November 27, 2019

10.0K

Acute Liver Failure Induced by Menopausal Supplement.

Rahul Patel1, Ahmed Hassan1, Hayle Scanlan2

  • 1Department of Internal Medicine, Jefferson Health, Washington Township, NJ.

ACG Case Reports Journal
|September 23, 2024
PubMed
Summary

A woman taking the herbal supplement Provitalize developed severe drug-induced liver injury. Despite stopping the supplement, her condition rapidly worsened, leading to liver failure and death.

Keywords:
ALFDILIacute liver failuredrug induced liver injuryherbal and dietary supplementsmenopause supplementmoringapiperineturmeric

More Related Videos

Inducing Acute Liver Injury in Rats via Carbon Tetrachloride CCl4 Exposure Through an Orogastric Tube
06:12

Inducing Acute Liver Injury in Rats via Carbon Tetrachloride CCl4 Exposure Through an Orogastric Tube

Published on: April 28, 2020

11.3K
Rat Model of the Associating Liver Partition and Portal Vein Ligation for Staged Hepatectomy ALPPS Procedure
07:29

Rat Model of the Associating Liver Partition and Portal Vein Ligation for Staged Hepatectomy ALPPS Procedure

Published on: August 14, 2017

14.7K

Related Experiment Videos

Last Updated: Jun 12, 2025

Generation of a Rat Model of Acute Liver Failure by Combining 70% Partial Hepatectomy and Acetaminophen
09:44

Generation of a Rat Model of Acute Liver Failure by Combining 70% Partial Hepatectomy and Acetaminophen

Published on: November 27, 2019

10.0K
Inducing Acute Liver Injury in Rats via Carbon Tetrachloride CCl4 Exposure Through an Orogastric Tube
06:12

Inducing Acute Liver Injury in Rats via Carbon Tetrachloride CCl4 Exposure Through an Orogastric Tube

Published on: April 28, 2020

11.3K
Rat Model of the Associating Liver Partition and Portal Vein Ligation for Staged Hepatectomy ALPPS Procedure
07:29

Rat Model of the Associating Liver Partition and Portal Vein Ligation for Staged Hepatectomy ALPPS Procedure

Published on: August 14, 2017

14.7K

Area of Science:

  • Hepatology
  • Toxicology
  • Integrative Medicine

Background:

  • Drug-induced liver injury (DILI) is a significant cause of acute liver failure.
  • Herbal and alternative supplements are increasingly used but can pose risks.
  • Identifying novel causes of DILI is crucial for patient safety.

Observation:

  • A menopausal woman used Provitalize for hot flashes and bloating.
  • She presented with jaundice and elevated liver enzymes.
  • Her condition rapidly deteriorated to encephalopathy and multiorgan failure.

Findings:

  • This case report details the first instance of liver injury linked to the herbal supplement Provitalize.
  • The patient's liver injury progressed rapidly despite discontinuation of the supplement.
  • The clinical course was characterized by severe hepatotoxicity and a fatal outcome.

Implications:

  • Provitalize may be a potential cause of drug-induced liver injury.
  • Healthcare providers should inquire about supplement use in patients with acute liver injury.
  • Further investigation into the hepatotoxicity of Provitalize is warranted.