A metabolic-inflammatory-nutritional score (MINS) is associated with lymph node metastasis and prognostic stratification for endometrial cancer patients

Xite Lin ^1,2,3, Tianai Chen ^1,2,3, Liang Wang ^1,2,3,4

⁰Laboratory of Gynecologic Oncology, Fujian Maternity and Child Health Hospital, College of Clinical Medicine for Obstetrics & Gynecology and Pediatrics, Fujian Medical University, Fuzhou 350001, China.

International Journal of Medical Sciences +

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September 23, 2024

View abstract on PubMed

Summary

A new metabolic-inflammatory-nutritional score (MINS) predicts lymph node metastasis (LNM) in endometrial cancer (EC). This score aids in stratifying high-risk patients, especially those with a family history of Lynch syndrome-associated cancers (LSAC).

Area Of Science

Oncology
Genetics
Biostatistics

Background

Endometrial cancer (EC) poses a significant health challenge, with lymph node metastasis (LNM) being a critical prognostic factor.
Patients with a family history of Lynch syndrome-associated cancers (LSAC) represent a distinct subgroup requiring tailored risk assessment.

Purpose Of The Study

To develop and validate a personalized prediction model, the metabolic-inflammatory-nutritional score (MINS), for LNM in EC.
To assess the predictive value of MINS for survival in EC patients with a family history of LSAC.

Main Methods

Utilized logistic regression and LASSO for feature selection to construct the MINS from data of 676 EC patients.
Employed Kaplan-Meier analysis and log-rank tests to evaluate survival probabilities.
Developed and validated a prognostic nomogram using concordance index (C-index) and calibration plots.

Main Results

MINS and a family history of LSAC were significantly associated with LNM risk (adjusted p<0.05).
High-risk MINS group and family history of LSAC correlated with poorer overall survival (p=0.038 and p=0.001, respectively).
The developed nomogram demonstrated strong predictive accuracy with a C-index of 0.778.

Conclusions

Preoperative MINS is a valuable predictor of LNM risk in EC patients.
A MINS-based prognostic nomogram offers effective risk stratification for EC patients, particularly those with a family history of LSAC.

Keywords:

Endometrial cancer Inflammation Lymph node metastasis Metabolism Nutrition