Spontaneous Air Embolism Following Contrast Injection: A Diagnostic Challenge in a Post-COVID-19 Patient

A 72-year-old male with a complex medical history, including chronic obstructive pulmonary disease (COPD), hypertension, atrial fibrillation, and a recent COVID-19 infection, presented to the emergency department with shortness of breath and chest pain. Physical examination revealed stable vital signs but notable bilateral decreased air entry and diffuse wheezing. A computed tomography angiogram (CTA) of the chest confirmed a small to moderate volume of air embolism within the main pulmonary artery and right ventricle, with no evidence of pulmonary embolism. The air embolism was suspected to have been introduced during a contrast injection for the CT scan, as no other iatrogenic factors, recent invasive procedures, or history of lung trauma were present. Initial management included repositioning the patient to a supine position and administering 100% oxygen, which was critical in stabilizing his condition. Despite the ongoing symptoms of shortness of breath, the patient's condition improved with supportive care focused on managing COPD exacerbation. Spontaneous air embolism without decompression sickness or prior instrumentation is exceptionally rare, particularly in a post-COVID-19 patient, making this case notable. It highlights the critical need for prompt recognition, thorough evaluation, and appropriate management of air embolism in complex medical scenarios to prevent life-threatening complications. This case also underscores the importance of considering iatrogenic causes, such as contrast injection, in the differential diagnosis, especially following recent imaging studies.