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Structure and function of the T cell receptor/T3 complex.

C Terhorst

    Progress in Clinical and Biological Research
    |January 1, 1985
    PubMed
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    The T cell receptor (TCR)/T3 complex on human lymphocytes has distinct roles. The alpha/beta chains recognize antigens, while the T3 complex, possibly via T3-epsilon, transduces signals, including Ca2+ influx, to initiate T cell responses.

    Area of Science:

    • Immunology
    • Molecular Biology
    • Cell Biology

    Background:

    • The T cell receptor (TCR)/T3 complex is crucial for human T cell activation.
    • The TCR complex comprises variable alpha/beta chains and invariant gamma, delta, epsilon chains.
    • Genes for TCR alpha, beta, and delta chains have been identified.

    Purpose of the Study:

    • To elucidate the functional roles of TCR/T3 complex components in T cell activation.
    • To investigate the signal transduction pathway initiated by antigen recognition.
    • To explore the potential role of T3-epsilon in calcium ion (Ca2+) influx.

    Main Methods:

    • Functional studies involving human thymus-derived lymphocytes.
    • Analysis of T cell receptor-ligand interactions.

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  • Investigation of signal transduction mechanisms, including calcium flux.

    • Main Results:

    • A division of labor exists between TCR alpha/beta chains and T3 gamma, delta, epsilon chains.
    • TCR alpha/beta chains mediate antigen and MHC product recognition.
    • The T3 complex transduces activating signals, with Ca2+ influx playing a key role.

    Conclusions:

    • T cell responses are initiated upon ligand binding via the TCR/T3 complex.
    • The T3 complex is essential for signal transduction following antigen recognition.
    • The T3-epsilon chain is hypothesized to function as a calcium gate, mediating Ca2+ influx.