Related Experiment Video
Updated: Jun 12, 2025

Author Spotlight: Understanding Microbe Adaptation Using Innovative Techniques for Exploring Thermophilic Evolution
Published on: June 14, 2024
Thermodynamic dissipation does not bound replicator growth and decay rates
1ICREA-Complex Systems Lab, Universitat Pompeu Fabra, 08003 Barcelona, Spain and Universal Biology Institute, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.
Abstract:
In a well-known paper, Jeremy England derived a bound on the free energy dissipated by a self-replicating system [J. L. England, "Statistical physics of self-replication," J. Chem. Phys. 139, 121923 (2013)]. This bound is usually interpreted as a universal relationship that connects thermodynamic dissipation to replicator per-capita decay and growth rates. We argue from basic thermodynamic principles against this interpretation. In fact, we suggest that such a relationship cannot exist in principle, because it is impossible for a thermodynamically consistent replicator to undergo both per-capita growth and per-capita decay back into reactants. Instead, replicator may decay into separate waste products, but in that case, replication and decay are two independent physical processes, and there is no universal relationship that connects their thermodynamic and dynamical properties.
Related Concept Videos
Second Law of Thermodynamics
Third Law of Thermodynamics
Entropy and the Second Law of Thermodynamics
The relation between entropy and disorder can be illustrated with the example of the phase change of ice to water. In ice, the molecules are located at specific sites giving a solid state, whereas, in a liquid form, these molecules are much freer to move. The molecular arrangement has therefore become more randomized. Although the change in average...
Zeroth Law of Thermodynamics
Statements of the Second Law of Thermodynamics
The Second Law of Thermodynamics

