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Cercosporin-Photocatalyzed [4+1]- and [4+2]-Annulations of Azoalkenes Under Mild Conditions
Published on: July 17, 2020
Organotellurium (IV) complexes as anti-malarial agents: synthesis, characterization and computational insights
Anisha Bhardwaj1, Amit Dubey2,3, Aisha Tufail3
1Department of Chemistry, Maharshi Dayanand University, Rohtak, 124001, Haryana, India.
Abstract:
Aim: To synthesize and evaluate the antimalarial and antioxidant activities of novel organotellurium (IV) thiophene-based complexes.Materials & methods: Synthesized complexes were characterized using NMR, IR and mass spectrometry. Their biological activities were assessed using in vitro assays and molecular docking studies.Results: The complexes exhibited significant antimalarial activity against Plasmodium falciparum, with the highest activity observed for complexes 5b and 5e. ADMET properties confirmed their potential as therapeutic agents.
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