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Related Experiment Video

Updated: Jun 13, 2025

Use of a Video Scoring Anchor for Rapid Serial Assessment of Social Communication in Toddlers

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Positive Autism Screening Rates in Toddlers Born During the COVID-19 Pandemic.

Morgan R Firestein¹, Angela Manessis², Jennifer M Warmingham³

¹Department of Psychiatry, Columbia University Irving Medical Center, New York, New York.

JAMA Network Open

|September 23, 2024

Summary

Prenatal pandemic exposure did not increase autism screening positivity in children. Maternal SARS-CoV-2 infection during pregnancy was linked to lower rates of positive Modified Checklist for Autism in Toddlers, Revised (M-CHAT-R) screenings.

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Published on: December 7, 2018

Area of Science:

Neurodevelopmental conditions
Pregnancy and viral illness
Autism screening

Background:

Prenatal stress and viral infections are linked to neurodevelopmental issues.
The impact of the COVID-19 pandemic on autism screening rates is not well understood.

Purpose of the Study:

To investigate the association between prenatal exposure to the pandemic and maternal SARS-CoV-2 infection with positive Modified Checklist for Autism in Toddlers, Revised (M-CHAT-R) screening rates.

Main Methods:

Two cohorts (COMBO-EHR and COMBO-RSCH) were analyzed.
M-CHAT-R scores from children aged 16-30 months were abstracted from EHRs and collected prospectively.
Prenatal pandemic exposure and maternal SARS-CoV-2 infection were determined via EHRs.

Main Results:

Neither prenatal pandemic exposure nor maternal SARS-CoV-2 infection was associated with increased M-CHAT-R positivity in the COMBO-EHR cohort.
Maternal SARS-CoV-2 infection was associated with a *lower* rate of M-CHAT-R positivity in the COMBO-EHR cohort (aOR, 0.40; P=.001).
No significant association was found in the COMBO-RSCH cohort for SARS-CoV-2 infection.

Conclusions:

Prenatal pandemic exposure and maternal SARS-CoV-2 infection were not associated with increased autism screening positivity.
Further research is needed to understand the complex interplay between prenatal exposures and child neurodevelopment.