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Sedentary and 21 gastrointestinal disorders: A Mendelian randomization study
Yunzhi Lin1, Jun He, Zhen Ding
1Department of Hepatobiliary Surgery, Chaohu Hospital of Anhui Medical University, Hefei, China.
Medicine
|September 23, 2024
Summary
Sedentary behavior, like prolonged TV viewing, is causally linked to an increased risk of nine gastrointestinal disorders. This Mendelian randomization study provides new insights into the connection between lifestyle and gut health.
Area of Science:
- Genetics
- Gastroenterology
- Epidemiology
Background:
- Observational studies suggest a link between sedentary behavior (SB) and gastrointestinal illnesses, but causality remains unclear.
- Understanding the genetic underpinnings of this association is crucial for public health.
- Previous research has not definitively established a causal relationship between SB and specific GI disorders.
Purpose of the Study:
- To investigate the potential causal relationship between genetically predicted sedentary behavior and 21 common gastrointestinal disorders using Mendelian randomization.
- To identify specific gastrointestinal conditions associated with sedentary behavior.
- To provide robust evidence on the link between lifestyle factors and gastrointestinal health.
Main Methods:
- Utilized Mendelian randomization (MR) analysis with instrumental variables for SB (TV viewing, computer use, driving) from UK Biobank.
- Obtained genetic associations for 21 gastrointestinal disorders from the FinnGen research.
- Employed inverse-variance weighted (IVW), MR-Egger, and weighted median methods for robust analysis, adjusting for confounders.
Main Results:
- Genetic susceptibility to prolonged television viewing was significantly associated with an increased risk of 9 out of 21 gastrointestinal disorders.
- Specifically identified were gastroesophageal reflux disease, chronic gastritis, cholelithiasis, acute pancreatitis, chronic pancreatitis, gastroduodenal ulcer, fatty liver, irritable bowel syndrome, and acute appendicitis.
- These associations remained significant after adjusting for confounding factors and were confirmed by replication analysis.
Conclusions:
- This study demonstrates a genetically supported causal relationship between sedentary behavior, particularly prolonged television viewing, and an increased risk of several gastrointestinal disorders.
- The findings highlight the importance of reducing sedentary time for gastrointestinal health.
- Further research is warranted to elucidate the underlying pathogenic mechanisms connecting sedentary behavior and gastrointestinal diseases.
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