Ecosystemic Approach to Understanding Gut Microbiome-Mediated Prevention of Colorectal Cancer

Area of Science:

• Microbiology
• Oncology
• Nutritional Science

Background:

• Host-associated microbiota are integral to human health and disease.
• The gut microbiota, particularly colonic bacteria, are implicated in colorectal cancer (CRC) development.
• Emerging research identifies specific microbes (oncomicrobes) and their metabolites (oncometabolites) linked to carcinogenesis.

Purpose of the Study:

• To emphasize the gut microbiome as a complex ecosystem for cancer prevention.
• To highlight the impact of dietary patterns on gut microbial health.
• To identify whole food-derived dietary fiber as a key factor for gut eubiosis and cancer prevention.

Main Methods:

• Review of current scientific literature on gut microbiota and colorectal cancer.
• Analysis of the role of dietary patterns in modulating the gut microbial ecosystem.
• Focus on the impact of whole food-derived dietary fiber on gut health.

Main Results:

• The gut microbiome functions as an ecosystem influencing disease and health.
• Dietary patterns significantly shape the gut microbial ecosystem's health-promoting or disease-promoting qualities.
• Whole food-derived dietary fiber is a critical component for establishing a healthy gut eubiosis.

Conclusions:

• Viewing the gut microbiome as an ecosystem is essential for effective cancer prevention strategies.
• Dietary interventions targeting the gut microbiome, specifically through increased fiber intake, can promote eubiosis and potentially prevent colorectal cancer.
• Shifting towards whole food-based diets is crucial for mitigating chronic disease burden.