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Related Experiment Video

Updated: Jun 12, 2025

Prediction and Validation of Gene Regulatory Elements Activated During Retinoic Acid Induced Embryonic Stem Cell Differentiation

Prediction and Validation of Gene Regulatory Elements Activated During Retinoic Acid Induced Embryonic Stem Cell Differentiation

Published on: June 21, 2016

Three transposable elements exhibiting differential expression in pre-eclampsia overlap with enhancer regions.

Laura M Keighley¹, Chiemi F Lynch-Sutherland², Lorissa McDougall¹

¹Department of Pathology, Dunedin School of Medicine, University of Otago, Dunedin 9054, New Zealand.

|September 23, 2024

Summary

Transposable elements (TEs) are vital for placental development. Our study found that altered TE expression in pre-eclampsia (PE) suggests TEs may regulate genes, contributing to PE pathogenesis.

Keywords:

Placenta Placental development Pre-eclampsia Transposable elements

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Published on: January 26, 2024

Area of Science:

Genetics
Reproductive Biology
Genomic Regulation

Background:

Transposable elements (TEs) are mobile DNA sequences influencing genome evolution and gene regulation.
TEs are implicated in various biological processes, including placental development.
Dysregulation of TEs is increasingly recognized in complex diseases.

Purpose of the Study:

To investigate the role of transposable element (TE) expression in pre-eclampsia (PE).
To identify specific TEs with altered expression in PE placental tissues.
To explore the potential regulatory functions of dysregulated TEs in PE pathogenesis.

Main Methods:

Utilized RNA-sequencing (RNA-seq) to analyze TE expression profiles in PE and control placental samples.
Performed differential expression analysis to identify significantly altered TEs.
Mapped the genomic locations of key TEs and assessed their overlap with regulatory elements like enhancers.

Main Results:

Identified several differentially expressed transposable elements (TEs) in pre-eclampsia (PE) placental tissues.
Discovered that three significant TEs are located within putative enhancer regions.
These findings suggest a potential mechanism for TE-mediated gene dysregulation in PE.

Conclusions:

Transposable element (TE) dysregulation is associated with pre-eclampsia (PE).
TEs located in enhancer regions may play a regulatory role in PE pathogenesis.
Further research into TE function is crucial for understanding and potentially treating PE.