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Desthiobiotin-Streptavidin-Affinity Mediated Purification of RNA-Interacting Proteins in Mesothelioma Cells
Published on: April 25, 2018
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Noncoding RNA network crosstalk in organ fibrosis
Hui Ling1, Xian-Chen Wang1, Zhi-Yan Liu2
1Department of Thoracic Surgery, The Second Affiliated Hospital of Anhui Medical University, Hefei 230601, China.
Cellular Signalling
|September 23, 2024
Summary
Non-coding RNAs (ncRNAs), including long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs), play a critical role in organ fibrosis by regulating microRNAs (miRNAs). This axis offers new therapeutic targets for treating fibrotic diseases.
Area of Science:
- Molecular Biology
- Genetics
- Pathophysiology
Background:
- Fibrosis is characterized by excessive extracellular matrix accumulation, impairing organ function.
- Non-coding RNAs (ncRNAs) are increasingly recognized for their crucial roles in the development of organ fibrosis.
Purpose of the Study:
- To elucidate the role of the ncRNA/miRNA/mRNA axis in organ fibrosis.
- To identify potential ncRNA-based therapeutic targets for fibrotic diseases.
Main Methods:
- Review and summarization of existing studies on ncRNA interactions.
- Analysis of the ceRNA network involving lncRNAs, circRNAs, miRNAs, and mRNAs.
Main Results:
- lncRNAs and circRNAs function as competing endogenous RNAs (ceRNAs), sponging miRNAs.
- The lncRNA/circRNA-miRNA-mRNA axis is implicated in fibrosis across multiple organs (heart, liver, kidney, spleen).
Conclusions:
- The ncRNA/miRNA/mRNA regulatory network is central to the pathophysiology of organ fibrosis.
- Targeting ncRNAs presents a promising strategy for novel anti-fibrotic therapies.
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