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Comprehensive Autopsy Program for Individuals with Multiple Sclerosis

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Alexia without agraphia: from infarctions to malignancies.

Ruben Jauregui¹, Julia Greenberg², Philip Kuball²

¹Department of Neurology, NYU Grossman School of Medicine, New York, New York, USA rjaureg91@gmail.com.

Practical Neurology

|September 23, 2024

Summary

This summary is machine-generated.

Alexia without agraphia, a reading impairment, results from specific brain lesions. This condition underscores the need for comprehensive language assessments in patients with visual field deficits.

Keywords:

CLINICAL NEUROLOGY DISCONNECTION NEUROANATOMY NEUROOPHTHALMOLOGY STROKE

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Area of Science:

Neurology
Neuroscience
Clinical Neurology

Background:

Alexia without agraphia is a rare neurological condition characterized by the inability to read while preserving the ability to write.
This syndrome is typically associated with distinct lesions in the splenium of the corpus callosum and the occipital lobe of the dominant hemisphere.
Splenial lesions disrupt communication between language and visual processing areas, while occipital lesions can cause visual field deficits like homonymous hemianopia.

Purpose of the Study:

To describe two cases of alexia without agraphia with lesions affecting the splenium and dominant occipital lobe.
To emphasize the clinical significance of thorough language evaluation in patients presenting with homonymous visual field deficits.

Main Methods:

Case study approach describing two patients with specific neurological lesions.
Clinical assessment focusing on reading, writing, and visual field deficits.

Main Results:

Both patients presented with alexia without agraphia due to lesions in the splenium and dominant occipital lobe.
The underlying causes of the lesions differed between the two patients.
The findings highlight a potential diagnostic challenge where reading and writing impairments might be overlooked.

Conclusions:

The co-occurrence of splenium and dominant occipital lobe lesions can lead to alexia without agraphia.
Clinicians must conduct comprehensive language assessments in patients with homonymous visual field deficits to avoid misdiagnosis.
Early identification of alexia without agraphia is crucial for appropriate patient management.