A cluster-randomised controlled feasibility trial evaluating the Cognitive Occupation-Based programme for people with...

Area of Science:

• Neuroscience
• Rehabilitation Science
• Occupational Therapy

Background:

• Cognitive difficulties are prevalent in Multiple Sclerosis (MS), impacting daily life.
• Existing cognitive programs often lack focus on functional, everyday living skills.
• The Cognitive Occupation-Based programme for people with Multiple Sclerosis (COB-MS) was developed to address these gaps.

Purpose of the Study:

• To evaluate the feasibility and initial efficacy of the COB-MS intervention.
• To assess COB-MS as a cognitive intervention for individuals with MS.
• To determine if COB-MS meets progression criteria for a definitive trial.

Main Methods:

• A cluster-randomised controlled feasibility trial was conducted.
• The COB-MS intervention was delivered remotely by occupational therapists over eight sessions.
• Data on cognition, quality of life, mood, and functional outcomes (Goal Attainment Scaling) were collected at multiple time points.

Main Results:

• 118 participants with MS and cognitive difficulties were randomized (58 to COB-MS, 60 to usual care).
• The COB-MS intervention was found to be feasible, acceptable to participants, and demonstrated positive impacts on daily life.
• A significant improvement in the primary outcome (Goal Attainment Scaling) was observed in the COB-MS group compared to the control group.

Conclusions:

• The feasibility trial met its progression criteria, supporting further investigation.
• Results provide a strong basis for a definitive trial of COB-MS.
• The COB-MS shows preliminary clinical efficacy for individuals with MS experiencing cognitive challenges.