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Programmed cell death and melatonin: A comprehensive review.
Mahdi Rafiyian1,2, Russel J Reiter3, Sayyed Mehdi Rasooli Manesh4
1Student Research Committee, Kashan University of Reiter Sciences, Kashan, Iran.
Melatonin (MLT) influences cellular homeostasis and programmed cell death (PCD). This review summarizes MLT
Area of Science:
- Endocrinology and Cell Biology
- Molecular Biology
Background:
- Melatonin (MLT), a hormone from the pineal gland, regulates cellular homeostasis.
- MLT's widespread receptors suggest broad physiological influence.
- Programmed cell death (PCD) is crucial for development and organ function.
Purpose of the Study:
- To review the role of MLT in modulating PCD across various diseases.
- To elucidate the mechanisms by which MLT influences PCD pathways.
Main Methods:
- Literature review of studies investigating MLT's effects on PCD.
- Synthesis of findings on MLT's direct and indirect modulation of PCD mechanisms.
Main Results:
- MLT demonstrates significant effects on various PCD pathways.
- MLT's modulation of PCD is implicated in the treatment of diverse diseases.
- Specific mechanisms of MLT's influence on PCD are highlighted.
Conclusions:
- MLT is a promising therapeutic agent for diseases involving PCD.
- Understanding MLT's role in PCD offers insights into novel treatment strategies.
- Further research into MLT-PCD interactions is warranted.
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