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Evaluation of prognostic efficacy of liver immune status index in predicting postoperative outcomes in hepatocellular carcinoma patients: A multi-institutional retrospective study

  • 0Department of Gastroenterological and Transplant Surgery, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan.
Journal of Hepato-Biliary-Pancreatic Sciences +

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September 24, 2024

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September 24, 2024

View abstract on PubMed

Summary

This summary is machine-generated.

The liver immune status index (LISI) effectively predicts recurrence and survival in hepatocellular carcinoma (HCC) patients, especially those with vascular invasion. A new HISCO-HCC score further refines prognosis for personalized HCC treatment.

Area Of Science

  • Hepatobiliary surgery
  • Surgical oncology
  • Immunology

Background

  • Hepatocellular carcinoma (HCC) is a leading cause of cancer mortality worldwide.
  • High recurrence rates after hepatectomy, particularly with liver fibrosis and hepatitis C virus, remain a clinical challenge.
  • Natural killer (NK) cells play a vital role in anti-tumor immunity against circulating tumor cells in HCC.

Purpose Of The Study

  • To validate the liver immune status index (LISI) for predicting NK cell antitumor efficiency in HCC patients.
  • To assess LISI's predictive performance, especially in HCC patients with vascular invasion.

Main Methods

  • Retrospective analysis of 1337 primary HCC hepatectomies.
  • Evaluation of prognostic indices including LISI, FIB-4, ALBI, ALICE, GNRI, and APRI using ROC curve analysis.
  • Survival analyses conducted using Kaplan-Meier estimations and log-rank tests.

Main Results

  • LISI correlated with other prognostic markers and stratified patients by overall survival (OS) and recurrence rates (RR).
  • LISI demonstrated superior predictive performance for 2-year OS and RR, particularly in patients with vascular invasion.
  • The novel HISCO-HCC score, integrating LISI, tumor burden, and alpha-fetoprotein, enhanced prognostic accuracy.

Conclusions

  • LISI is a superior predictive tool for HCC, outperforming existing models, especially in cases with vascular invasion.
  • The HISCO-HCC score provides enhanced prognostic precision for guiding immunotherapeutic strategies and personalized patient care in HCC.

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