Assessing Seminal Plasma Malondialdehyde Acid as a Diagnostic Tool for Male Infertility: A Case-Control Study

Area of Science:

• Reproductive biology
• Biochemistry
• Clinical diagnostics

Background:

• Global rise in male and female infertility rates.
• Need for reliable diagnostic markers in reproductive medicine.

Purpose of the Study:

• Assess seminal Malondialdehyde Acid (MDA) role in male infertility diagnosis.
• Evaluate MDA impact on semen parameters in fertile and infertile men.
• Determine MDA efficacy for diagnosing male infertility.

Main Methods:

• Case-control study involving 90 infertile and 90 fertile men.
• Biochemical analysis of seminal MDA levels using Human MDA Assay kits.
• Correlation of MDA levels with semen parameters like motility, concentration, and morphology.

Main Results:

• Significantly higher mean MDA levels in infertile men (1.03 ± 0.31 mmol/mL) vs. fertile men (0.60 ± 0.14 mmol/mL).
• Negative association between seminal MDA and sperm motility, concentration, and morphology.
• MDA demonstrated 86.67% sensitivity and 76.67% specificity for predicting male infertility.

Conclusions:

• Seminal MDA is a potential biomarker for male infertility.
• Further large-scale prospective studies are needed to validate MDA's predictive accuracy.