Related Experiment Video
Updated: Jun 12, 2025
Evaluation of Antimicrobial Activities of Nanoparticles and Nanostructured Surfaces In Vitro
Published on: April 21, 2023
Antibacterial Effect of Co-Loaded Curcumin and Rutin in Mesoporous Silica Nanoparticles Compared to their Loading
Mohammad Yousef Memar1, Mina Yekani2,3, Simin Sharifi4
1Infectious and Tropical Diseases Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Aims:
The present study aimed to assess the antibacterial effect of co-loaded rutin and curcumin in mesoporous silica nanoparticles (Cur-Rut-MSNs).
Background:
Rutin is a nontoxic phytochemical that is present expansively in vegetables and fruits. Curcumin is an active ingredient of Curcuma longa. Curcumin and rutin have a variety of therapeutic effects, essentially antimicrobial, anti-inflammatory, and antioxidant actions.
Objective:
Low aqueous solubility and poor bioavailability of rutin and curcumin limit their application in therapeutic goals. One of the advantageous routes to improve their bioavailability and solubility is nanoformulation. Co-delivery of therapeutic agents has been reported to have better therapeutic effects than monotherapy.
Methods:
The present study has evaluated the antibacterial properties of Cur-Rut-MSNs. The Minimum Inhibitory Concentration (MIC) of Cur-Rut-MSNs has been assessed against different bacteria.
Results:
Cur-Rut-MSNs exerted significantly higher antibacterial effect than curcumin-loaded MSNs (Cur-MSNs) and rutin-loaded MSNs (Rut-MSNs) against Acinetobacter baumannii, Escherichia coli, Staphylococcus aureus, and Enterococcus faecalis (p<0.05).
Conclusion:
The antibacterial effect was enhanced by the co-loading of rutin and curcumin in MSNs. According to the findings of this study, Cur-Rut-MSNs exhibit an antibacterial effect and can be a favorable nanoformulation against planktonic bacteria.
