Visceral and subcutaneous adiposity and cardiovascular disease: Unravelling associations and prognostic value
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View abstract on PubMed
Summary
This summary is machine-generated.Visceral adipose tissue (VAT) and waist circumference (WC) better predict coronary heart disease (CHD) risk than abdominal subcutaneous adipose tissue (ASAT). Measuring VAT alongside WC improves cardiovascular disease risk assessment.
Area Of Science
- Cardiology
- Radiology
- Public Health
Background
- Abdominal adiposity distribution is linked to cardiovascular disease (CVD) risk.
- Waist circumference (WC) is a common but imprecise measure of abdominal fat, failing to distinguish visceral adipose tissue (VAT) from abdominal subcutaneous adipose tissue (ASAT).
- Accurate assessment of abdominal adiposity is crucial for predicting CVD events.
Purpose Of The Study
- To compare the prognostic value of elevated VAT and ASAT versus elevated WC for CVD events in the general population.
- To determine if VAT or ASAT offers greater predictive power for coronary heart disease (CHD) than WC.
- To investigate the association of different abdominal fat depots with CHD, stroke, heart failure (HF), and atrial fibrillation (AF).
Main Methods
- Secondary analysis of UK Biobank data including 24,265 participants with abdominal MRI data.
- Primary outcome: coronary heart disease (CHD); Secondary outcomes: stroke, heart failure (HF), and atrial fibrillation (AF).
- Cox regression models were used to assess the risk associated with VAT, ASAT, and WC, examining both continuous and categorical (concordant/discordant) values.
Main Results
- Increased VAT (HR 1.15) and ASAT (HR 1.10) were associated with higher CHD risk per 1 SD increase.
- After adjusting for WC, the association between ASAT and CHD risk was eliminated, while the VAT-CHD association remained significant.
- Discordant measurements (e.g., high VAT with low WC) showed increased CHD risk (HR 1.43-1.46), whereas discordant ASAT did not.
- Neither VAT nor ASAT showed an association with stroke, HF, or AF risk after adjusting for WC.
Conclusions
- Incorporating VAT measurements with WC improves CHD risk identification compared to WC alone.
- VAT and WC are more accurate CHD risk indicators than ASAT.
- VAT alone does not fully explain the CHD risk associated with elevated WC.
- Neither VAT nor ASAT are associated with risks of stroke, HF, or AF after adjusting for WC.
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