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Global Burden of Inflammatory Bowel Disease Among Children and Adolescents: A Comprehensive Analysis (1990-2019)
Xuejie Chen1, Xin Xiang1, Xiaofei Fan2
1Department of Gastroenterology, Third Xiangya Hospital of Central South University, Changsha, Hunan, China.
Insights
Global inflammatory bowel disease (IBD) incidence in children and adolescents rose 22.8% from 1990-2019. Despite a global decrease in disease burden (DALYs), high SDI regions saw no improvement, indicating a need for targeted interventions.
Area of Science:
- Pediatric Gastroenterology
- Epidemiology
- Global Health
Background:
- Inflammatory bowel disease (IBD) encompasses Crohn's disease and ulcerative colitis, affecting children and adolescents globally.
- Understanding the epidemiological trends and disease burden of pediatric IBD is crucial for public health planning.
Purpose of the Study:
- To analyze the global, regional, and national burden of inflammatory bowel disease (IBD) in children and adolescents.
- To assess temporal trends in IBD incidence and disability-adjusted life years (DALYs) from 1990 to 2019.
Main Methods:
- Utilized data from the Global Burden of Disease Study 2019.
- Analyzed pediatric IBD data by sex, age, year, and location.
- Employed Joinpoint analysis to evaluate disease burden trends.
Main Results:
- Global IBD incidence in children and adolescents increased by 22.8% between 1990 and 2019.
- Overall DALYs decreased by 53.5%, but high Socio-demographic Index (SDI) regions showed no improvement.
- In 2019, early-onset IBD incidence was 2,053.52 and DALYs were 73,797.46.
Conclusions:
- Early-onset IBD in pediatric populations is a significant global health issue.
- The disease burden has not improved in developed countries over the last three decades.
- Targeted interventions are necessary, particularly for high SDI regions.
Objective:
We summarize the global, regional, and national burden of inflammatory bowel disease (IBD) in children and adolescents from 1990 to 2019.
Methods:
Based on the Global Burden of Disease Study 2019, the data of IBD in children and adolescents were analyzed by sex, age, year, and location. Joinpoint analysis was applied to assess the temporal trend of the disease burden.
Results:
From 1990 to 2019, the incidence of IBD in children and adolescents increased by 22.8%, from 20,897.42 to 25,658.55 cases, especially in high SDI region. During the same period, the DALY numbers decreased by 53.5%, from 243,081.06 to 113,119.86, with all SDI regions experiencing a clear drop in DALYs except high SDI regions. In 2019, early-onset IBD incidence and DALY numbers were reported at 2,053.52 (95% UI: 1,575.62 to 2,677.49) and 73,797.46 (95% UI: 43,655.86 to 105,998.63), respectively.
Conclusion:
Early-onset IBD in children and adolescents remains a significant global health concern. The disease burden has not improved in developed countries over the past 30 years, highlighting the need for targeted interventions.
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