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Isolation and Quantification of Epstein-Barr Virus from the P3HR1 Cell Line
Published on: September 28, 2022
Ocular tuberculosis associated with Epstein-Barr virus myelitis: A case report
Fakhri Alahyari1, Raheleh Halabian2, Javad Hosseini Nejad1
1Neuroscience Research Center, Baqiyatallah University of Medical Sciences, Tehran, 14359-44711, Iran.
Abstract:
Ocular tuberculosis (OTB) is a chronic eye infection caused by Mycobacterium tuberculosis. Some cases of myelitis are associated with Epstein-Barr virus (EBV), with 1-5% of EBV infections leading to neurologic complications. We describe a 34-year-old Iranian woman with OTB and EBV coinfection. Despite initial success with anti-TB agents, the disease progressed, necessitating enucleation. Mycobacterium tuberculosis was detected by a tuberculin coagulation test, and EBV was confirmed via polymerase chain reaction. MRI showed plaques in the spinal cord and brain. The patient was treated with anti-TB and antiretroviral agents. Recognizing TB in the differential diagnosis of EBV myelitis is crucial.
Insights
Ocular tuberculosis (OTB) and Epstein-Barr virus (EBV) coinfection can lead to severe neurological complications. Early recognition of tuberculosis is vital for diagnosing EBV myelitis.
Area of Science:
- Ophthalmology
- Infectious Diseases
- Neurology
Background:
- Ocular tuberculosis (OTB) is a chronic infection caused by Mycobacterium tuberculosis.
- Epstein-Barr virus (EBV) can cause myelitis, a spinal cord inflammation, in 1-5% of infections.
- Coinfection with OTB and EBV presents unique diagnostic and therapeutic challenges.
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