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Updated: Jun 12, 2025
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Rapid Decline of Mpox Antibody Responses Following MVA-BN Vaccination
Ai-Ris Y Collier1, Katherine McMahan1, Catherine Jacob-Dolan1
1Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.
Abstract:
The replication-incompetent modified vaccinia Ankara-Bavarian Nordic vaccine (MVA-BN; Jynneos) was deployed during the 2022 clade IIb mpox outbreak. On August 14, 2024, the World Health Organization declared the mpox clade Ib outbreak in the Democratic Republic of the Congo a public health emergency of international concern, which has raised the question about the durability of vaccine immunity after MVA-BN vaccination. In this study, we show that the MVA-BN vaccine generated mpox serum antibody responses that largely waned after 6-12 months.
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