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Schmidt´s syndrome found by tan: a case report
Gabriela Venade1, Catarina Almeida1, Nídia Oliveira1
1Internal Medicine Department, Centro Hospitalar Tondela Viseu, Viseu, Portugal.
The Pan African Medical Journal
|September 24, 2024
Summary
Addison's disease, a component of autoimmune polyglandular syndrome, was diagnosed in a patient with hypothyroidism and vitiligo. Early diagnosis and treatment with hormone replacement therapy led to a good clinical response.
Area of Science:
- Endocrinology
- Immunology
- Case Reports
Background:
- Addison's disease can be part of type 2 autoimmune polyglandular syndrome.
- Early diagnosis is crucial for managing autoimmune endocrine disorders.
Observation:
- A 41-year-old female presented with worsening asthenia, anorexia, nausea, and weight loss.
- Physical examination revealed cutaneous hyperpigmentation and vitiligo.
- Laboratory tests showed low serum cortisol, elevated ACTH, and positive antiperoxidase and 17-alpha-hydroxylase antibodies.
Findings:
- The patient was diagnosed with Addison's disease, likely secondary to autoimmune polyglandular syndrome.
- Treatment with prednisolone and fludrocortisone resulted in significant clinical improvement.
Implications:
- This case highlights the importance of maintaining a high clinical suspicion for Addison's disease.
- Active screening for associated autoimmune conditions is recommended in patients with suspected Addison's disease.
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