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Updated: Jun 12, 2025

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Schmidt´s syndrome found by tan: a case report.

Gabriela Venade1, Catarina Almeida1, Nídia Oliveira1

  • 1Internal Medicine Department, Centro Hospitalar Tondela Viseu, Viseu, Portugal.

The Pan African Medical Journal
|September 24, 2024
PubMed
Summary

Addison's disease, a component of autoimmune polyglandular syndrome, was diagnosed in a patient with hypothyroidism and vitiligo. Early diagnosis and treatment with hormone replacement therapy led to a good clinical response.

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Area of Science:

  • Endocrinology
  • Immunology
  • Case Reports

Background:

  • Addison's disease can be part of type 2 autoimmune polyglandular syndrome.
  • Early diagnosis is crucial for managing autoimmune endocrine disorders.

Observation:

  • A 41-year-old female presented with worsening asthenia, anorexia, nausea, and weight loss.
  • Physical examination revealed cutaneous hyperpigmentation and vitiligo.
  • Laboratory tests showed low serum cortisol, elevated ACTH, and positive antiperoxidase and 17-alpha-hydroxylase antibodies.

Findings:

  • The patient was diagnosed with Addison's disease, likely secondary to autoimmune polyglandular syndrome.
  • Treatment with prednisolone and fludrocortisone resulted in significant clinical improvement.
Keywords:
Addison’s diseaseSchmidt´s syndromeautoimmune polyglandular syndromecase report

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Implications:

  • This case highlights the importance of maintaining a high clinical suspicion for Addison's disease.
  • Active screening for associated autoimmune conditions is recommended in patients with suspected Addison's disease.