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The ubiquitin-proteasome system in the tumor immune microenvironment: a key force in combination therapy

Yongmei Wang1, Saisai Li2, Wenqin Wang3

  • 1Breast Disease Center, The Affiliated Hospital of Qingdao University, Qingdao, Shandong, China.

Frontiers in Immunology
|September 24, 2024
PubMed

Insights

The ubiquitin-proteasome system (UPS) regulates immune cells and tumor microenvironments. Targeting the UPS with immunotherapy offers a promising strategy to enhance anti-tumor responses and improve cancer treatment outcomes.

Area of Science:

  • Immunology
  • Cancer Biology
  • Molecular Biology

Background:

  • The ubiquitin-proteasome system (UPS) is vital for immune cell function and protein regulation.
  • UPS influences immune checkpoint proteins, impacting T cell anti-tumor responses and tumor immune escape.
  • UPS remodeling of the tumor immunosuppressive microenvironment (TIME) involves various immune cells.

Purpose of the Study:

  • To review the role of the UPS in the TIME.
  • To explore the interaction of the UPS with immune cells within the TIME.
  • To investigate the potential of combining UPS-targeted therapies with immunotherapy.

Main Methods:

  • Literature review focusing on UPS function in immune cells and TIME.
  • Analysis of UPS involvement in immune checkpoint regulation.
  • Exploration of combination strategies involving UPS inhibitors and immunotherapy.

Main Results:

  • The UPS significantly modulates immune cell proliferation, activation, and function.
  • UPS activity impacts T cell-mediated anti-tumor immunity and tumor immune evasion.
  • UPS plays a key role in shaping the TIME by regulating B cells, dendritic cells, macrophages, and Treg cells.

Conclusions:

  • Targeting the UPS, especially in combination with immune checkpoint inhibitors, can enhance anti-tumor immunity.
  • Combining UPS-targeted therapies with immunotherapy presents a novel strategy for cancer treatment.
  • This approach holds potential for improving treatment efficacy and patient survival outcomes.
Keywords:
TIMEUPScancerimmune cellsimmunotherapy

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