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Pharmacomicrobiomics in precision cancer therapy: bench to bedside
Khanh Le Ngoc1, Tran Thu Ha Pham1, Tiep Khac Nguyen1
1Faculty of Biotechnology, Hanoi University of Pharmacy, Hanoi, Vietnam.
Abstract:
The burgeoning field of pharmacomicrobiomics offers promising insights into the intricate interplay between the microbiome and cancer, shaping responses to diverse treatment modalities. This review aims to analyze the molecular mechanisms underlying interactions between distinct microbiota types and cancer, as well as their influence on treatment outcomes. We explore how the microbiome impacts antitumor immunity, and response to chemotherapy, immunotherapy, and radiation therapy, unveiling its multifaceted roles in cancer progression and therapy resistance. Moreover, we discuss the challenges hindering the development of microbiome-based interventions in cancer therapy, including standardization, validation, and clinical translation. By synthesizing clinical evidence, we underscore the transformative potential of harnessing pharmacomicrobiomics in guiding cancer treatment decisions, paving the way for improved patient outcomes in clinical practice.
Insights
Pharmacology and the microbiome (microbiome) significantly impact cancer treatment outcomes. Understanding these interactions can personalize cancer therapies for better patient results.
Area of Science:
- Pharmacology and microbiome research
- Cancer biology and treatment
Background:
- The microbiome plays a crucial role in cancer development and progression.
- Microbiome composition influences patient responses to various cancer therapies.
- Pharmacology is increasingly recognizing the impact of microbial communities.
Purpose of the Study:
- To analyze the molecular mechanisms of microbiome-cancer interactions.
- To investigate the microbiome's influence on chemotherapy, immunotherapy, and radiation therapy.
- To explore the potential of pharmacomicrobiomics in cancer treatment.
Main Methods:
- Review of existing clinical evidence and scientific literature.
- Analysis of molecular mechanisms linking microbiota and cancer.
- Synthesis of data on microbiome's role in treatment resistance and antitumor immunity.
Main Results:
- The microbiome significantly affects antitumor immunity and responses to cancer treatments.
- Microbiota composition is linked to therapy resistance and overall cancer progression.
- Pharmacological interventions can be modulated by the microbiome.
Conclusions:
- Pharmacological applications of microbiome research (pharmacomicrobiomics) hold transformative potential for cancer therapy.
- Understanding microbiome-cancer interactions is key to guiding personalized treatment decisions.
- Further research is needed to overcome challenges in clinical translation of microbiome-based interventions.
