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NCOA3 knockdown delays human embryo development.

Zhaoting Wu1, Xueshan Ma1,2, Jingyu Wang3

  • 1Center for Reproductive Medicine, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450000, China.

Heliyon
|September 24, 2024
PubMed
Summary
This summary is machine-generated.

Nuclear receptor coactivator 3 (NCOA3) is crucial for human embryonic development. Low NCOA3 levels impair embryo quality and developmental potential, impacting assisted reproductive technologies.

Keywords:
Embryo developmentMetabolismNANOGNCOA3Single-oocyte RNA sequencing

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Area of Science:

  • Reproductive Biology
  • Developmental Biology
  • Molecular Endocrinology

Background:

  • Embryonic development is critical for IVF success, with oocyte and embryo quality being key factors.
  • Nuclear receptor coactivator 3 (NCOA3) is known for its role in tumorigenesis and maintaining pluripotency in mouse stem cells.
  • The function of NCOA3 in human embryonic development is largely unknown.

Purpose of the Study:

  • To investigate the role of NCOA3 in regulating human embryonic development.
  • To explore the relationship between NCOA3 expression and embryo quality.
  • To understand the molecular mechanisms by which NCOA3 influences human embryo development.

Main Methods:

  • Collection of human oocytes, zygotes, and embryos.
  • Immunofluorescence and quantitative real-time PCR (qPCR) for expression analysis.
  • Microinjection and RNA sequencing for functional and mechanistic studies.

Main Results:

  • NCOA3 expression was significantly lower in human embryos with poor quality ( >50% fragmentation).
  • NCOA3 expression correlated with the pluripotency factor NANOG.
  • NCOA3 deletion was observed to delay human embryonic development and affect oocyte metabolism.

Conclusions:

  • NCOA3 plays a pivotal role in human embryonic development, influencing developmental potential.
  • NCOA3 deletion compromises embryo developmental capacity.
  • These findings offer insights into improving assisted reproductive technologies and understanding embryonic developmental disorders.