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Related Experiment Video

Updated: Jun 12, 2025

Body Composition and Metabolic Caging Analysis in High Fat Fed Mice

Body Composition and Metabolic Caging Analysis in High Fat Fed Mice

Published on: May 24, 2018

Orexins mitigate obesity-associated dysfunctions in mice.

Anne Blais¹, Isabelle Denis¹, Mireille Andriamihaja¹

¹UMR-PNCA, Université Paris-Saclay, AgroParisTech, Palaiseau, France.

Obesity (Silver Spring, Md.)

|September 24, 2024

Summary

Orexin-A treatment reduced weight gain and improved metabolic health in obese mice. This suggests orexin receptors are potential therapeutic targets for treating obesity and its related complications.

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Last Updated: Jun 12, 2025

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Published on: May 24, 2018

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Assessment of the Metabolic Effects of Isocaloric 2:1 Intermittent Fasting in Mice

Published on: November 27, 2019

Area of Science:

Neuroscience
Metabolic Research
Obesity Studies

Background:

Obesity is a widespread chronic disease with significant comorbidities.
Orexins, hypothalamic neuropeptides, play a role in physiological processes linked to obesity.

Purpose of the Study:

To investigate the effects of chronic orexin-A administration in mouse models of obesity.
To evaluate the role of orexin signaling in metabolic flexibility.

Main Methods:

Utilized obesity-prone and resistant C57BL/6 mice, and orexin receptor-deficient mice fed a high-fat diet.
Assessed glucose tolerance, indirect calorimetry, neuropeptide/receptor expression, microglial activation, and gut microbiota.

Main Results:

Orexin-A administration decreased weight gain, body fat, food intake, and insulin resistance in obesity-prone mice.
Observed alterations in intestinal microbiota composition and reduced hypothalamic expression of orexin receptors and feeding-related neuropeptides.
Orexin-A treatment mitigated steatosis and improved metabolic flexibility.

Conclusions:

Orexin receptor signaling is implicated in energy metabolism regulation.
Targeting orexin receptors may offer a novel therapeutic strategy for managing obesity and associated metabolic dysfunctions.