Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Mouse Models of Cancer Study

Mouse Models of Cancer Study

Mice have long served as models for studying human biology and pathology because of their phylogenetic and physiological similarity with humans. They are also easy to maintain and breed in the laboratory, and hence, many inbred strains are now available for research. Studies on mice have contributed immeasurably to our understanding of cancer biology.
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Evaluation of 2,2'-dimorpholinodiethyl ether (DMDEE) in pathology, perinatal, and genotoxicity studies.

Toxicology·2026

Same author

Tox21mer, A transformer foundation model for Tox21 high-throughput concentration-response curves data.

bioRxiv : the preprint server for biology·2026

Same author

Gestational and lactational exposure to HIV tri-combination therapy induces sex- and dose-dependent changes in inflammatory cytokine profiles, intestinal permeability, and villi morphology in adult rat offspring.

Frontiers in immunology·2026

Same author

Power calculations for larval zebrafish in light-dark transition test for developmental neurotoxicity.

Neurotoxicology·2025

Same author

Environmental, Social, and Health Burdens in relation to Sleep-Disordered Breathing among Patients of Community-Based Health Centers in the United States.

medRxiv : the preprint server for health sciences·2025

Same author

Assessing replicability and power estimates of behavioral performance of control rats across standardized pre-clinical and toxicology studies.

Neurotoxicology and teratology·2025

Search research articles

Related Experiment Video

Updated: Jun 12, 2025

A Protocol for Using Gene Set Enrichment Analysis to Identify the Appropriate Animal Model for Translational Research

A Protocol for Using Gene Set Enrichment Analysis to Identify the Appropriate Animal Model for Translational Research

Published on: August 16, 2017

Simulation methodologies to determine statistical power in laboratory animal research studies.

Angela Jeffers¹, Kathryn Konrad¹, Gary Larson¹

¹Social & Scientific Systems, Inc., Durham, NC, USA.

Laboratory Animals

|September 24, 2024

Summary

Conducting power analyses using simulations before experiments is crucial for reproducible laboratory animal research. This approach validates statistical tests, ensuring reliable and ethical findings aligned with animal welfare principles.

Keywords:

4R principles Statistical power reproducibility sample size statistical simulations

More Related Videos

Novel Object Recognition and Object Location Behavioral Testing in Mice on a Budget

Novel Object Recognition and Object Location Behavioral Testing in Mice on a Budget

Published on: November 20, 2018

Behavioral and Locomotor Measurements Using an Open Field Activity Monitoring System for Skeletal Muscle Diseases

Behavioral and Locomotor Measurements Using an Open Field Activity Monitoring System for Skeletal Muscle Diseases

Published on: September 29, 2014

Related Experiment Videos

Last Updated: Jun 12, 2025

A Protocol for Using Gene Set Enrichment Analysis to Identify the Appropriate Animal Model for Translational Research

A Protocol for Using Gene Set Enrichment Analysis to Identify the Appropriate Animal Model for Translational Research

Published on: August 16, 2017

Novel Object Recognition and Object Location Behavioral Testing in Mice on a Budget

Novel Object Recognition and Object Location Behavioral Testing in Mice on a Budget

Published on: November 20, 2018

Behavioral and Locomotor Measurements Using an Open Field Activity Monitoring System for Skeletal Muscle Diseases

Behavioral and Locomotor Measurements Using an Open Field Activity Monitoring System for Skeletal Muscle Diseases

Published on: September 29, 2014

Area of Science:

Laboratory animal research
Statistical methodology
Animal welfare

Background:

Null hypothesis significance testing is standard in animal research.
Reproducibility of experimental results is paramount.
Robust statistical methods are essential for valid and reproducible findings.

Purpose of the Study:

To highlight the importance of power analyses in laboratory animal research.
To demonstrate the utility of simulation studies for assessing statistical power.
To advocate for pre-experimental power analysis to ensure reproducibility and ethical animal use.

Main Methods:

Utilized simulation studies to assess statistical test power.
Applied methods to simulated Harlan Sprague-Dawley (HSD) rat organ weight data.
Demonstrated the process of conducting power analyses prior to experimentation.

Main Results:

Simulation studies are an effective and accessible method for determining statistical power.
Pre-experimental power analysis validates statistical tests.
This approach supports the 4R principles of animal welfare.

Conclusions:

Power analyses are critical for ensuring the reproducibility and validity of laboratory animal research.
Simulation studies offer a reliable and practical means to conduct power analyses.
Implementing power analyses contributes to financially and ethically sound research practices.