Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Types of Toxins

Types of Toxins

Humans continually engage with an environment rich in potentially harmful chemicals. These are introduced to our bodies through inhalation, ingestion, or skin contact. These chemicals exist in various forms, such as air and environmental pollutants, agricultural chemicals, organic solvents, and heavy metals.
Air pollutants, primarily gases, pose significant threats to respiratory health, leading to conditions like hypoxia, lung cancer, and in extreme cases, death.
Environmental pollutants like...

Toxic Reactions: Overview

Toxic Reactions: Overview

When toxic substances penetrate the human body, they disseminate to various tissues, undergoing metabolic changes. This process yields reactive metabolites that may covalently bind with specific target molecules, resulting in toxicity.
Toxicity falls into two primary categories: local and systemic.
Local toxicity appears at the exposure site, such as protein denaturation caused by caustic substances.
In contrast, systemic toxicity requires the toxic agent's absorption and distribution,...

Bioplastics

Bioplastics

Bioplastics derived from microbial processes present a sustainable alternative to conventional petroleum-based plastics. Among these, polyhydroxyalkanoates (PHAs), particularly polyhydroxybutyrates (PHBs), have emerged as prominent candidates due to their biodegradability and biocompatibility. These polymers are synthesized by a variety of bacteria, such as Cupriavidus necator and Pseudomonas putida, which naturally accumulate PHAs as intracellular carbon and energy reserves, especially under...

Microbial Bioremediation of Plastics

Microbial Bioremediation of Plastics

Polyethylene terephthalate (PET) is a synthetic polymer widely utilized in the packaging industry, particularly for bottles and containers. Due to its chemical stability and durability, PET accumulates in the environment, contributing significantly to plastic pollution. It comprises repeating units of terephthalic acid and ethylene glycol, resulting in a semi-crystalline structure that is resistant to natural degradation processes.A notable breakthrough in plastic biodegradation came with the...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Ecotoxicological Impacts of Perfluorooctane Sulfonate on the Freshwater Snail <i>Lanistes carinatus</i>: Oxidative Stress, Neurotoxicity, and Histopathological Alterations.

International journal of molecular sciences·2025

Same author

Effects of Gabapentin, Valsartan, and Codeine on hemato-biochemical and histological biomarkers of male catfish (Clarias gariepinus).

Environmental science and pollution research international·2025

Same author

Effect of early administration of inhaled heparin on outcomes of smoke inhalation injury: A randomized controlled trial.

Burns : journal of the International Society for Burn Injuries·2025

Same author

Role of Crepis rueppellii Leaf Extract Against Paracetamol-Inducing Nephrotoxicity in Guinea Pigs: A Histological, Immunohistochemical, and Biochemical Study.

Microscopy and microanalysis : the official journal of Microscopy Society of America, Microbeam Analysis Society, Microscopical Society of Canada·2025

Same author

Role of gallic acid against hepatic functional and histological deteriorations in tartrazine-intoxicated rats.

Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association·2025

Same author

Synergistic effects of thermal stress and 4-nonylphenol on oxidative stress and immune responses in juvenile tilapia (Oreochromis niloticus).

Environmental science and pollution research international·2024

Search research articles

Related Experiment Video

Updated: Jun 24, 2026

An Intravital Microscopy-Based Approach to Assess Intestinal Permeability and Epithelial Cell Shedding Performance

An Intravital Microscopy-Based Approach to Assess Intestinal Permeability and Epithelial Cell Shedding Performance

Published on: December 3, 2020

Microplastics induced ileum damage: Morphological and immunohistochemical study.

Shaimaa M M Saleh¹, Souzan Abdel-Zaher², Mahmoud S Mohamed¹

¹Department of Zoology, Faculty of Science, Assiut University, Assiut, Egypt.

Microscopy Research and Technique

|September 24, 2024

Summary

Exposure to polyethylene microplastics (MPs) caused significant damage to the mammalian ileum, including cell changes and tissue deformation. A recovery period helped to ameliorate most of these adverse effects.

Keywords:

Ki‐67 expression goblet cells mice plastics pyknosis

More Related Videos

A Murine Model of Fetal Exposure to Maternal Inflammation to Study the Effects of Acute Chorioamnionitis on Newborn Intestinal Development

A Murine Model of Fetal Exposure to Maternal Inflammation to Study the Effects of Acute Chorioamnionitis on Newborn Intestinal Development

Published on: June 24, 2020

Postoperative Ileus Murine Model

Postoperative Ileus Murine Model

Published on: July 12, 2024

Related Experiment Videos

Last Updated: Jun 24, 2026

An Intravital Microscopy-Based Approach to Assess Intestinal Permeability and Epithelial Cell Shedding Performance

An Intravital Microscopy-Based Approach to Assess Intestinal Permeability and Epithelial Cell Shedding Performance

Published on: December 3, 2020

A Murine Model of Fetal Exposure to Maternal Inflammation to Study the Effects of Acute Chorioamnionitis on Newborn Intestinal Development

A Murine Model of Fetal Exposure to Maternal Inflammation to Study the Effects of Acute Chorioamnionitis on Newborn Intestinal Development

Published on: June 24, 2020

Postoperative Ileus Murine Model

Postoperative Ileus Murine Model

Published on: July 12, 2024

Area of Science:

Environmental Science
Toxicology
Gastroenterology

Background:

Microplastics (MPs), particularly polyethylene (PE), are pervasive environmental pollutants.
While combined effects with other chemicals are studied, the impact of single-use PE MPs on mammalian ileum remains under-researched.

Purpose of the Study:

To investigate the cellular-level effects of polyethylene microplastic (PE MP) exposure on the ileum of C57BL/6 mice.
To assess the impact of varying PE MP concentrations and a subsequent recovery period on intestinal tissue.

Main Methods:

Mice were exposed to different concentrations of PE MPs (6, 60, 600 μg/mL) for 15 days, followed by a 15-day recovery period.
Histology, histochemistry (Alcian blue, PAS), immunohistochemistry (P53, Ki-67), and transmission electron microscopy were employed to analyze ileal tissue.

Main Results:

PE MP exposure induced nuclear pyknosis, villus deformation, lamina propria degeneration, and goblet cell hyperplasia with increased secretion.
Significant upregulation of P53 and Ki-67 expression was observed, especially at higher MP concentrations.
Ultrastructural analysis confirmed MP deposition within cells.

Conclusions:

Single-use polyethylene microplastics cause significant morphological and cellular damage to the mammalian ileum.
A recovery period can largely reverse the observed alterations, suggesting potential for intestinal healing.
Further research is needed to understand the long-term implications of microplastic ingestion.