Related Experiment Video
Updated: May 2, 2026
Establishment of a Human Multiple Myeloma Xenograft Model in the Chicken to Study Tumor Growth, Invasion and Angiogenesis
Published on: May 1, 2015
Angiogenesis and multiple myeloma: Exploring prognostic potential of adrenomedullin
Angelos Giannakoulas1, Panagiotis Stoikos1, Evangelia Kouvata2
1Laboratory of Hematology Department, Faculty of Medicine, University of Thessaly, Larissa, Greece.
Background:
Adrenomedullin (AM) is a multifunctional peptide which under basal conditions mainly regulates vasodilation and maintains vascular integrity but is also implicated in the pathogenesis of several malignancies, including multiple myeloma (MM). It has been shown that adrenomedullin is expressed by human myeloma cell lines and that it enhances MM-driven angiogenesis. However, the clinical impact of AM remains unknown.
Materials And Methods:
On that basis, we enrolled 32 newly diagnosed multiple myeloma patients (NDMM) and studied the potential of AM as a prognostic biomarker.
Results:
We report that elevated levels of AM trend with suboptimal treatment response and inferior survival of NDMM patients.
More Related Videos
05:32Multimodal Bioluminescent and Positronic-emission Tomography/Computational Tomography Imaging of Multiple Myeloma Bone Marrow Xenografts in NOG Mice
Published on: January 7, 2019
07:41A Robust Discovery Platform for the Identification of Novel Mediators of Melanoma Metastasis
Published on: March 8, 2022
