Related Experiment Video
Updated: May 16, 2026

A Protocol to Acquire the Degenerative Tenocyte from Humans
Published on: June 9, 2018
[Histopathological diagnostics for assessment questions of tendo-, ligamento-, and meniscus pathologies]
Veit Krenn1, Lara Blümke2, Ralf Dieckmann3
1Medizinisches Versorgungszentrum (MVZ) für Histologie, Zytologie und Molekulare Diagnostik Trier GmbH, Max-Planck-Straße 5, 54296, Trier, Deutschland. veit.krenn@patho-trier.de.
Abstract:
This review article presents the possibilities and limitations of histopathological diagnostics on the issues of joint diseases, including in the context of the medical insurance inquiries, which consider the important articular, non-osseous compartments, especially of the tendons, ligaments, and meniscus. Essential for expert assessments is the causal clarification of whether the continuity disruption has been induced exogenously by trauma or endogenously based on tissue that is functionally impaired and thus degeneratively altered. The degree of degeneration/texture disorder is determined by means of the degeneration-score, which is set in a semiquantitative, three-stage grading. Grades 1 and 2 are summed up as low-grade degeneration and compared to grade 3, high-grade degeneration. Age determination of continuity disruption is based on the assessment of the morphology of discontinuity and on the assessment of hemosiderin deposits. The tasks of histopathological diagnostics thus consist of the detection and grading of textural disorder (degeneration), the determination of the histopathologic age of existing continuity disruptions, and particularly the diagnosis of clinically/radiologically undiagnosed diseases, which may be relevant for pathogenesis. In the case of contradictory diagnoses from different diagnostic disciplines and in the case of imprecise and potentially even contradictory patient information, purely legal, judicial decisions may be necessary. In this case the legally binding assessment within the framework of legal evidence evaluation then arises.
Related Concept Videos
Assessment of the Abdomen III: Palpation
Assessment of the Abdomen II: Percussion
Percussion
Percussion is an essential...
Assessment of the Rectum and Anus
Rectal Inspection
Begin by inspecting the perianal and anal areas for color, texture, rashes,...
Serum Laboratory Studies, Stool Test, Breath Test
Nursing Assessment of the Genitourinary System II: Inspection and Palpation
Nursing Assessment of the Genitourinary System III: Percussion and Auscultation

