The benefits (or detriments) of adapting to demand disruptions in a hospital pharmacy with supply chain disruptions

  • 0Department of Industrial and Operations Engineering, University of Michigan, 1205 Beal Ave, Ann Arbor, MI, 48109, USA. czernL@umich.edu.

|

|

Summary

This summary is machine-generated.

Hospital pharmacies can optimize drug inventory by adapting policies to demand changes. A drug

Area Of Science

  • Operations Research
  • Healthcare Management
  • Supply Chain Management

Background

  • Hospital pharmacy managers face challenges in inventory control due to supply chain and demand disruptions.
  • Insufficient inventory causes drug shortages, while excess inventory leads to drug waste.
  • Adapting inventory policies can mitigate shortages and waste, especially during demand fluctuations like the COVID-19 pandemic.

Purpose Of The Study

  • To investigate how a drug's shortage-waste weighting and supply chain disruption characteristics influence the benefits of adaptive inventory policies.
  • To develop and analyze an adaptive inventory system for hospital pharmacies.
  • To identify which drugs require policy updates to maximize the benefits of adaptive inventory management.

Main Methods

  • Developed an adaptive inventory system where policies change over time.
  • Conducted extensive numerical analysis using real-world demand data from a university hospital pharmacy.
  • Created a ranking procedure to prioritize drugs for inventory policy updates.

Main Results

  • A drug's shortage-waste weighting significantly impacts the benefits or detriments of adaptive inventory policies.
  • For fixed supply chain disruption parameters, weighting is the primary driver of adaptive policy effectiveness.
  • A small proportion of drugs (<math></math>) require updates to achieve maximum benefits from adaptive policies.

Conclusions

  • Drug shortage-waste weighting is critical in determining the value of adaptive inventory policies in hospital pharmacies.
  • A practical ranking procedure can guide decision-makers in prioritizing inventory policy updates.
  • Adaptive inventory management, when strategically applied to a small subset of drugs, offers substantial benefits for mitigating shortages and waste.

Related Concept Videos

Issues And Trends In Healthcare Delivery System 01:29

5.6K

The issues and trends in healthcare delivery are constantly changing. The COVID-19 pandemic is one recent issue that wreaked havoc on healthcare systems, causing a shortage of healthcare workers, high demand for medicines and supplies, and increased medical expenditure due to a lack of insurance. Other issues include rising healthcare costs and care fragmentation.
Cost Containment
Payment for healthcare services has historically promoted adoption of costly and often unnecessary or inefficient...

Pharmacovigilance 01:19

786

Post-marketing surveillance is a critical component of pharmaceutical regulation, often uncovering unanticipated adverse drug reactions (ADRs) once a drug is widely used over an extended period.
This process, termed pharmacovigilance, aims to detect, evaluate, and minimize harmful effects related to medication use. The data collection for pharmacovigilance depends on spontaneous reporting systems, where healthcare professionals or patients voluntarily report suspected ADRs.
In some cases, there...

Nonlinear Pharmacokinetics: Overview 01:19

309

Nonlinear or dose-dependent pharmacokinetics is a phenomenon that occurs when the pharmacokinetic parameters of certain drugs deviate from linear pharmacokinetics at higher doses. These drugs do not follow the expected first-order kinetics, where the rate of drug elimination is directly proportional to the drug concentration. Instead, they exhibit a nonlinear relationship, which can be attributed to several factors.
Nonlinearity can arise due to the saturation of plasma protein-binding or...

Factors Affecting Drug Response: Overview 01:21

1.9K

When it comes to infants and young children, they are typically administered smaller doses of medication in comparison to adults. This is primarily because their organ functions still need to fully develop, meaning their bodies are not as efficient at metabolizing or eliminating drugs. Additionally, their blood-brain barrier is more permeable than in adults. As a result, high concentrations of drugs can easily penetrate the central nervous system (CNS), potentially leading to neurological...

Chronopharmacokinetics: Circadian Rhythms and Influence on Drug Response 01:15

48

Circadian rhythms are cyclic changes that are crucial in plasma drug concentrations. Various standard circadian parameters, including core body temperature, heart rate, and other cardiovascular factors, directly impact disease states and the therapeutic response to drug therapy.
The time of drug administration is an important factor to consider, as it can influence the toxic dose of a drug. For example, a study conducted by Prins et al. in 1997 examined the effects of the timing of...

Drug Therapy 01:28

39

The advent of drug therapy has profoundly shaped modern mental health care, providing targeted treatments for a range of psychological disorders. Psychotherapeutic drugs, classified into antianxiety, antidepressant, and antipsychotic medications, address symptoms across anxiety disorders, mood disorders, and schizophrenia. While these medications have transformed patient outcomes, they require careful management due to their potential side effects and limitations.
Antianxiety Medications