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Indices and ferritin level that predict organ involvement in adult-onset Still's disease
Mehmet Nur Kaya1, Özlem Kılıç1, Ezgi Çimen Güneş1
1University of Health Sciences Turkey, Gülhane Training & Research Hospital, Rheumatology Department, Ankara, 38100, Turkey.
Insights
Inflammatory markers like lactate dehydrogenase to albumin ratio (LAR) and C-reactive protein to albumin ratio (CAR) can predict organ involvement in adult-onset Still's disease (AOSD). Ferritin levels and other indices also show predictive value for specific organ manifestations in AOSD patients.
Area of Science:
- Rheumatology
- Immunology
- Internal Medicine
Background:
- Adult-onset Still's disease (AOSD) is a rare systemic inflammatory disorder.
- Organ involvement is a significant complication in AOSD, impacting patient prognosis.
- Predictive markers for organ involvement in AOSD are crucial for early diagnosis and management.
Purpose of the Study:
- To evaluate the predictive value of various inflammatory and nutritional indices for organ involvement in AOSD.
- To assess the utility of C-reactive protein to albumin ratio (CAR), lactate dehydrogenase to albumin ratio (LAR), ferritin to erythrocyte sedimentation rate ratio (FER), systemic immune-inflammation index (SII), prognostic nutritional index (PNI), and ferritin level.
Main Methods:
- Cross-sectional study design.
- Inclusion of sixty-one adult patients diagnosed with AOSD.
- Application of univariate and multivariate logistic regression analyses to determine predictive capabilities of markers.
Main Results:
- Multivariate analysis identified LAR as a predictor of lymphadenopathy (OR 1.028, p=0.001).
- CAR predicted hepatomegaly (OR 1.249, p=0.002), and ferritin level predicted splenomegaly (OR 1.004, p=0.007).
- FER (OR 1.085, p=0.021) and PNI (OR 0.271, p<0.001) predicted serositis.
Conclusions:
- Ferritin level, CAR, FER, PNI, and LAR are potential predictors of organ involvement at diagnosis in AOSD.
- These markers can aid in identifying patients at risk for specific organ manifestations.
- Further research may validate these findings for clinical application in AOSD management.
Abstract:
Aim: The aim of the study is to evaluate whether C-reactive protein to albumin ratio (CAR), lactate dehydrogenase to albumin ratio (LAR), ferritin to erythrocyte sedimentation rate ratio (FER), systemic immune-inflammation index (SII), prognostic nutritional index (PNI) indices and ferritin level can predict organ involvement in adult-onset Still's disease (AOSD) patients.Methods: This study was planned as a cross-sectional study. Univariate and multivariate logistic regression analyses were performed to evaluate the usefulness of ferritin level and inflammatory indices in defining organ involvement.Results: Sixty-one patients diagnosed with AOSD were included in this study. Multivariate logistic regression analyzes showed that LAR (OR 1.028, 95% CI: 1.011-1.044) (p = 0.001) index predicted lymphadenopathy involvement, CAR (OR 1.249, 95% CI: 1.087-1.435) (p = 0.002) index predicted hepatomegaly involvement, ferritin level (OR 1.004, 95% CI: 1.001-1.008) (p = 0.007) predicted splenomegaly involvement, FER (OR 1.085, 95% CI: 1.012-1.164) (p = 0.021) and PNI (OR 0.271, 95% CI: 1.132-0.553) (p < 0.001) index predicted the occurrence of serositis.Conclusion: This study showed that ferritin level, CAR, FER, PNI and LAR markers may predict organ involvement at diagnosis in AOSD patients.
