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Updated: Jun 12, 2025

Neonatal Pial Surface Electroporation
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Neonatal pemphigus vulgaris

Sanmitra Aiholli1, Arun Inamadar2, Ajit B Janagond3

  • 1Dermatology, BLDE Deemed to be University, Vijayapura, Karnataka, India.

BMJ Case Reports
|September 24, 2024
PubMed

A neonate presented to a tertiary clinic with blisters and erosions over his trunk and extremities. The mother had multiple erosions with crusts affecting the scalp, oral cavity and trunk present since the first trimester and worse since delivery. Skin biopsy for histopathology and direct immunofluorescence confirmed pemphigus vulgaris (PV) in the mother. Indirect immunofluorescence assays for serum antibodies against desmogleins 1 and 3 were positive in both mother and baby confirming a diagnosis of neonatal PV. The baby's lesions healed spontaneously within 2 weeks, and the mother was clear at 2 months following treatment with rituximab.

Keywords:
DermatologyObstetrics, gynaecology and fertilityPaediatrics (drugs and medicines)

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