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Related Concept Videos

  1. Home
  3. Research Domains
  5. Biomedical And Clinical Sciences
  7. Oncology And Carcinogenesis
  9. Predictive And Prognostic Markers
  11. Evaluation Of Image-defined Risk Factor (idrf) Assessment In Patients With Intermediate-risk Neuroblastoma: A Report From The Children's Oncology Group Study Anbl0531.
  1. Home
  3. Research Domains
  5. Biomedical And Clinical Sciences
  7. Oncology And Carcinogenesis
  9. Predictive And Prognostic Markers
  11. Evaluation Of Image-defined Risk Factor (idrf) Assessment In Patients With Intermediate-risk Neuroblastoma: A Report From The Children's Oncology Group Study Anbl0531.

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Evaluation of Image-Defined Risk Factor (IDRF) Assessment in Patients With Intermediate-risk Neuroblastoma: A Report From the Children's Oncology Group Study ANBL0531.

Erin G Brown1, E Stanton Adkins2, Peter Mattei3

  • 1Division of Pediatric Surgery, Department of Surgery, University of California Davis Children's Hospital, Sacramento, CA, USA.

Journal of Pediatric Surgery
|September 24, 2024

View abstract on PubMed

Summary
This summary is machine-generated.
Keywords:
ConcordanceIDRFImage-defined risk factorNeuroblastoma

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The International Neuroblastoma Risk Group (INRG) classifier

Area of Science:

  • Pediatric oncology
  • Medical imaging
  • Cancer staging

Background:

  • The International Neuroblastoma Risk Group (INRG) classifier uses pretreatment imaging criteria, including image-defined risk factors (IDRFs), to stage neuroblastoma.
  • The Children's Oncology Group (COG) study ANBL0531 evaluated institutional IDRF assessments against standardized central review.

Purpose of the Study:

  • To compare the concordance of institutional IDRF assessments with central review in intermediate-risk neuroblastoma patients.
  • To identify discrepancies in IDRF interpretation between local and central review teams.

Main Methods:

  • Prospective enrollment of intermediate-risk neuroblastoma patients in COG study ANBL0531 (9/2009-6/2011).
  • Blinded central review of diagnostic imaging by paired COG pediatric surgeons and radiologists for IDRF presence.
  • Statistical comparison using the Kappa coefficient to assess concordance between local and central IDRF assessments.

    • Main Results:

    • Central reviewer pairs achieved moderate agreement on IDRF status (81.7%, κ = 0.48).
    • Local and central reviewers showed poor agreement on IDRF presence (51.9%, κ = 0.06).
    • Radiologists were significantly more likely than surgeons to identify IDRFs (p < 0.001).

    Conclusions:

    • Moderate concordance exists among experienced central reviewers for IDRF assessment.
    • Significant discordance between local and central IDRF evaluations highlights a need for improved standardization.
    • Enhanced standardization, education, technology, and training are crucial for accurate IDRF assessment in pediatric neuroblastoma.