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Proteases: Role in Various Human Diseases.
Ogireddy Sri Apoorva1, Khyati Shukla1, Aakash Khurana1
1Centre for Biotechnology & Biochemical Engineering, Amity Institute Biotechnology, Amity University Uttar Pradesh, Sector-125, Expressway, Noida, 201313, Uttar Pradesh, India.
Current Pharmaceutical Biotechnology
|September 25, 2024
Summary
Proteases are enzymes crucial for bodily functions but also drive diseases like cancer and neurodegeneration. Understanding protease roles is key for developing new disease treatments.
Area of Science:
- Biochemistry
- Molecular Biology
- Pathology
Background:
- Proteases are enzymes that break peptide bonds.
- They are vital for normal physiological functions.
- Dysregulated protease activity is linked to numerous diseases.
Purpose of the Study:
- To review the impact of protease activity in various disease contexts.
- To highlight the role of proteases in cancer, inflammation, cardiovascular, infectious, and neurodegenerative diseases.
- To emphasize the potential of proteases as therapeutic targets.
Main Methods:
- Literature review of studies on proteases and disease.
- Analysis of protease involvement in different pathological mechanisms.
- Synthesis of current understanding of protease functions in disease.
Main Results:
- Proteases contribute to tumor growth, invasion, and metastasis in cancer.
- They exacerbate tissue damage in inflammatory disorders.
- Proteases are involved in extracellular matrix remodeling in cardiovascular diseases.
- They aid pathogen invasion and immune evasion in infectious diseases.
- Protease dysregulation contributes to protein misfolding in neurodegenerative diseases.
Conclusions:
- Protease activity is a significant factor in the pathogenesis of diverse diseases.
- Targeting proteases offers potential for novel therapeutic strategies.
- Further research into protease-disease relationships is essential for clinical advancements.
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