Dual transition metal electrocatalysis enables selective C(sp3)-C(sp3) bond cleavage and arylation of cyclic alcohols
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Updated: Jun 12, 2025

Facile Preparation of 2Z,4E-Dienamides by the Olefination of Electron-deficient Alkenes with Allyl Acetate
Published on: June 21, 2017
Weixiang Li1, Ruipu Zhang1, Naifu Zhou1,2
1Beijing National Laboratory for Molecular Sciences, CAS Key Laboratory of Molecular Recognition and Function, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China. funiankai@iccas.ac.cn.
Abstract:
We report a dual transition metal electrocatalytic approach for C(sp3)-C(sp3) bond cleavage and arylation of cyclic alcohols, providing an efficient and sustainable method for site-specific arylation of ketones. The reaction involves electrophotochemical cerium-catalysed generation of alkoxyl radicals from readily accessible alcohols. Subsequently, homolytic cleavage of the β-C-C bond leads to the generation of carbon-centered radicals that could be effectively utilized by nickel catalysis powered by cathode reduction to deliver the remote arylated ketone products.
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