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Published on: June 2, 2014
Sumatriptan-naproxen sodium in migraine: A review
Robyn-Jenia Wilcha1, Shazia K Afridi2, Piero Barbanti3,4
1Headache Group, NIHR King's Clinical Research Facility and SLaM Biomedical Research Centre, The Wolfson Sensory, Pain and Regeneration Research Centre, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
Sumatriptan-naproxen sodium provides superior pain relief for migraine sufferers. This combination therapy offers greater initial and sustained pain freedom compared to individual medications or placebo.
Area of Science:
- Neurology
- Pharmacology
Background:
- Many patients experience inadequate relief from acute migraine treatments.
- Sumatriptan-naproxen sodium combines sumatriptan and naproxen sodium to target multiple migraine pathways.
Purpose of the Study:
- To review the efficacy and safety of sumatriptan-naproxen sodium for acute migraine treatment.
- To evaluate its effectiveness in diverse patient populations.
Main Methods:
- A narrative review of clinical trials involving sumatriptan-naproxen sodium was conducted.
- The review included studies on both adult and adolescent participants.
Main Results:
- Sumatriptan-naproxen sodium demonstrated superior efficacy in achieving 2-hour pain freedom (14/14 trials) and sustained pain relief up to 24 hours (13/14 trials).
- It was well-tolerated and effective in patients with allodynia, probable migraine, menstrual migraine, and those with prior poor responses to other acute treatments.
Conclusions:
- Multi-target therapies like sumatriptan-naproxen sodium can optimize acute migraine management.
- This combination therapy offers improved initial and sustained pain freedom for both adults and adolescents compared to monotherapy or placebo.
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