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Updated: Jun 12, 2025
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Formulating and Characterizing Lipid Nanoparticles for Gene Delivery using a Microfluidic Mixing Platform
Published on: February 25, 2021
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Lipid-based Non-viral Vector: Promising Approach for Gene Delivery
Anupama Panday1, Bhupendra Dixena1, Nishant Jain1
1Department of Pharmacy, Guru Ghasidas Vishwavidyalaya, Koni, Bilaspur, Chhattisgarh, India.
Current Pharmaceutical Design
|September 25, 2024
Summary
Non-viral vectors, particularly lipid nanocarriers, offer advantages for gene delivery by overcoming biological barriers. While challenges remain, their biocompatibility and cost-effectiveness show promise for gene therapy applications.
Area of Science:
- Biotechnology
- Nanomedicine
- Gene Therapy
Background:
- Gene delivery faces intracellular and extracellular barriers.
- Viral vectors have limitations in gene delivery.
- Non-viral vectors are emerging as alternatives.
Purpose of the Study:
- Review strategies for overcoming gene delivery barriers.
- Discuss advantages and challenges of non-viral vectors.
- Examine lipid-based carrier systems for gene delivery.
Main Methods:
- Literature search conducted on Google Scholar, ScienceDirect, PubMed, and Springer.
- Analysis of existing data on non-viral gene delivery vectors.
- Review of formulation approaches and clinical studies.
Main Results:
- Non-viral vectors show advantages over viral vectors in gene delivery.
- Lipid nanocarriers effectively overcome biological barriers for genetic material transport.
- Few non-viral vector systems are currently in clinical use.
Conclusions:
- Non-viral vector-based lipid nanocarriers are advantageous for gene delivery.
- Biocompatibility, synthesis ease, and cost-effectiveness make non-viral vectors attractive.
- Further research is needed for clinical translation and safety assessment.
