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Published on: September 1, 2011
The known and unknown of post-pump chorea: a case report on robust steroid responsiveness implicating occult
Muhammad Iqbal1, Muizz Zaman1, Niranjan Ojha1
1Department of Neurology, SUNY Upstate Medical University, Syracuse, NY, United States.
Abstract:
Post-pump chorea (PPC) is characterized by the development of choreiform movements following cardiopulmonary bypass (CPB) surgery. PPC occurs almost exclusively in children, and its pathophysiology remains unclear. Here we present an adult case of PPC after bovine aortic valve replacement (AVR) which exhibited dramatic and reproducible response to steroid, suggesting the presence of occult neuroinflammation. This observation suggests a novel underlying mechanism in certain subgroups of PPC, which is likely a heterogeneous condition to start with. Further research into the pathomechanisms of PPC could offer insights into managing this otherwise symptomatic control-only condition.
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