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Updated: Jul 30, 2026
Assessment of Vascular Function in Patients With Chronic Kidney Disease
Published on: June 16, 2014
Horizontal analysis and longitudinal cohort study of chronic renal failure correlates and cerebral small vessel
Dan Wang1, Zheng Sun1, Yuehua Li1
1Institute of Diagnostic and Interventional Radiology, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Background And Purpose:
Peak width of skeletonized mean diffusivity (PSMD) is an MRI-based biomarker that may reflect white matter lesions (WML). PSMD is based on skeletonization of MR DTI data and histogram analysis. Both chronic renal failure (CRF) and WML may be affected by multisystemic small-vessel disorder. We aimed to explore the relationship between PSMD and estimated glomerular filtration rate (eGFR).
Methods:
Fifty followed-up CRF patients matched for age, sex, hypertension and smoking status were enrolled and classified into a progressive group (n = 16) and stable group (n = 34) based on eGFR levels. Longitudinal and horizontal differences of PSMD were compared between the progressive and stable groups at the initial and follow-up time points. Pearson's correlation was used for correlation of eGFR with PSMD and WML (per Fazekas scale score). ROC was used to measure the sensitivity of PSMD and WML score to changes of eGFR.
Results:
At the follow-up time point, PSMD of the progressive group was significantly higher than at the initial time point (p < 0.001), and PSMD of the progressive group was significantly higher than stable group (p < 0.001). PSMD and eGFR were significantly correlated. AUC curves explored that ΔPSMD (PSMD changes at the follow-up and initial time points) and follow-up PSMD was better for the classification of progressive and stable groups.
Conclusion:
PSMD has significant correlation with eGFR, PSMD can reveal a close relationship between WML and CRF.
Insights
Peak width of skeletonized mean diffusivity (PSMD) correlates with estimated glomerular filtration rate (eGFR) in chronic renal failure (CRF) patients. PSMD may serve as a biomarker for white matter lesions (WML) in CRF.
Area of Science:
- Nephrology
- Neurology
- Radiology
Background:
- Chronic renal failure (CRF) and white matter lesions (WML) may share common underlying small-vessel disease.
- Peak width of skeletonized mean diffusivity (PSMD) is an MRI-based biomarker potentially reflecting WML.
- The relationship between PSMD and renal function (eGFR) in CRF patients is not well understood.
Purpose of the Study:
- To investigate the correlation between PSMD and estimated glomerular filtration rate (eGFR) in patients with CRF.
- To explore PSMD's potential as a biomarker for WML in the context of CRF.
Main Methods:
- Fifty CRF patients were categorized into progressive (n=16) and stable (n=34) groups based on eGFR.
- PSMD and WML (Fazekas score) were assessed at baseline and follow-up.
- Pearson's correlation and ROC analysis were used to evaluate the relationship between PSMD, eGFR, and WML.
Main Results:
- PSMD was significantly higher in the progressive group compared to the stable group at follow-up.
- A significant correlation was found between PSMD and eGFR.
- Changes in PSMD (ΔPSMD) and follow-up PSMD demonstrated good classification accuracy for progressive vs. stable groups.
Conclusions:
- PSMD shows a significant correlation with eGFR in CRF patients.
- PSMD may serve as a valuable biomarker reflecting the relationship between WML and CRF, potentially indicating disease progression.
