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Phenotypic characterization of people at risk of atrial fibrillation: protocol for the FIND-AF longitudinal cohort

Ali Wahab1,2,3, Ramesh Nadarajah1,2,3, Catherine Reynolds1,2

  • 1Leeds Institute of Data Analytics, Clarendon Way, University of Leeds, Leeds LS2 9DA, UK.

European Journal of Preventive Cardiology
|September 25, 2024
PubMed

Insights

The FIND-AF study will characterize patients at risk of atrial fibrillation (AF) using multi-modal phenotyping and home monitoring. This research aims to understand comorbidities

Area of Science:

  • Cardiology
  • Epidemiology
  • Biomarkers

Background:

  • Atrial fibrillation (AF) poses a significant health risk, necessitating improved detection and prevention strategies.
  • Identifying individuals at risk of AF early is crucial for timely intervention and management.
  • The Future Innovations in Novel Detection of Atrial Fibrillation (FIND-AF) study addresses this need through prospective cohort research.

Purpose of the Study:

  • To conduct a multi-modal phenotypic characterization of patients identified as at risk of atrial fibrillation (AF).
  • To investigate the impact of comorbidities on AF genesis.
  • To uncover actionable targets for AF prevention and establish a platform for clinical trials.

Main Methods:

  • Recruitment of 1955 participants aged 30+ identified as at risk of AF via the FIND-AF algorithm from primary care EHR data.
  • Home-based intermittent electrocardiogram monitoring for all participants.
  • Cross-sectional phenotypic characterization of ~500 participants without diagnosed AF, including physical examination, symptom assessment, blood biomarkers, echocardiography, and cardiac MRI.

Main Results:

  • Longitudinal data on cardio-renal-metabolic-pulmonary outcomes will be collected through EHR linkages.
  • Detailed phenotypic data will be gathered from a subset of participants.
  • The study is funded by the British Heart Foundation and has ethical approval.

Conclusions:

  • The FIND-AF study will provide evidence on the influence of comorbidities in AF development.
  • It aims to identify novel targets for AF prevention.
  • The study will serve as a foundation for future randomized clinical trials focused on AF detection and prevention.
Abstract

Keywords:
Atrial fibrillationCohortMultimodality imagingPhenotypingPreventionPrimary careProtocolRandomized clinical trial

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