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Body Roundness Index Trajectories and the Incidence of Cardiovascular Disease: Evidence From the China Health and
Man Yang1, Jia Liu1, Qian Shen1
1The Affiliated Wuxi Center for Disease Control and Prevention of Nanjing Medical University Wuxi Center for Disease Control and Prevention Wuxi China.
Insights
Higher body roundness index (BRI) trajectories are linked to increased cardiovascular disease (CVD) risk in older Chinese adults. BRI can serve as a valuable predictive factor for CVD incidence.
Area of Science:
- Cardiovascular Health
- Biometrics and Anthropometry
- Epidemiology
Background:
- Previous studies suggest a link between body roundness index (BRI) and cardiovascular disease (CVD).
- Longitudinal validation of this association is needed.
- This study investigates BRI trajectories and CVD risk in a Chinese cohort.
Purpose of the Study:
- To assess the association between body roundness index (BRI) trajectories and the risk of incident cardiovascular disease (CVD).
- To explore the predictive value of BRI trajectories in middle-aged and older Chinese adults.
Main Methods:
- Utilized data from 9935 participants in the China Health and Retirement Longitudinal Study (CHARLS) with repeated BRI measurements (2011-2016).
- Employed group-based trajectory modeling to identify BRI trajectories.
- Applied Cox proportional hazards regression to analyze the association between BRI trajectories and incident CVD (2017-2020).
Main Results:
- Identified three BRI trajectories: low-stable (49.81%), moderate-stable (42.35%), and high-stable (7.84%).
- Compared to the low-stable group, moderate-stable BRI trajectories showed a 1.22-fold increased CVD risk (aHR: 1.09-1.37), and high-stable trajectories showed a 1.55-fold increased risk (aHR: 1.26-1.90).
- Incorporating BRI trajectories improved CVD risk reclassification in conventional models.
Conclusions:
- A higher body roundness index (BRI) trajectory is significantly associated with an elevated risk of cardiovascular disease (CVD).
- Body roundness index (BRI) demonstrates potential as a predictive factor for cardiovascular disease (CVD) incidence.
Background:
Several previous cross-sectional studies suggested that body roundness index (BRI) may be associated with cardiovascular disease (CVD). However, the association should be further validated. Our study aimed to assess the association of the BRI trajectories with CVD among middle-aged and older Chinese people in a longitudinal cohort.
Methods And Results:
A total of 9935 participants from the CHARLS (China Health and Retirement Longitudinal Study) with repeated BRI measurements from 2011 to 2016 were included. The BRI trajectories were identified by group-based trajectory modeling. The primary outcome was incident CVD (stroke or cardiac events), which occurred in 2017 to 2020. Cox proportional hazards regression models were used to examine the association of BRI trajectories with CVD risk. Participants were divided into 3 BRI trajectories, named the low-stable BRI trajectory, moderate-stable BRI trajectory and high-stable BRI trajectory, accounting for 49.81%, 42.35%, and 7.84% of the study population, respectively. Compared with participants in the low-stable BRI trajectory group, those in the moderate-stable and high-stable BRI trajectory groups had an increased risk of CVD, with multivariable adjusted hazard ratios of 1.22 (95% CI, 1.09-1.37) and 1.55 (95% CI, 1.26-1.90), respectively. Furthermore, simultaneously adding the BRI trajectory to the conventional risk model improved CVD risk reclassification (all P<0.05).
Conclusions:
A higher BRI trajectory was associated with an increased risk of CVD. The BRI can be included as a predictive factor for CVD incidence.
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