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In vivo method to evaluate volumetric changes in bioceramic repair materials
Danilo Cassiano Ferraz1, Jader Camilo Pinto1, Juliane Maria Guerreiro-Tanomaru1
1Department of Restorative Dentistry, São Paulo State University (UNESP), School of Dentistry, Araraquara, SP, Brazil.
Brazilian Dental Journal
|September 25, 2024
Summary
Bioceramic root repair materials like Bio-C Repair and Biodentine exhibit superior volumetric stability compared to IRM, especially when assessed using an in vivo method rather than in vitro immersion solutions.
Area of Science:
- Biomaterials Science
- Dental Materials Research
- Regenerative Endodontics
Background:
- Bioceramic materials are increasingly used for root repair.
- Accurate assessment of volumetric stability is crucial for clinical success.
- In vitro methods may not fully replicate the in vivo environment.
Purpose of the Study:
- To compare the volumetric changes of Bio-C Repair (BCR) and Biodentine (BIO) against IRM.
- To evaluate the influence of in vitro immersion solutions versus an in vivo method on volumetric stability.
- To assess the suitability of an in vivo method for evaluating bioceramic properties.
Main Methods:
- Microcomputed tomography (µCT) was used for volumetric analysis.
- Materials were tested after setting and after 7-day immersion in distilled water, PBS, or rat subcutaneous tissue fluid.
- Polyvinyl chloride tubes were used as standardized sample holders.
Main Results:
- IRM showed significantly higher volumetric change than BCR and BIO in all immersion solutions.
- BCR and BIO exhibited similar volumetric changes in distilled water and PBS.
- In vivo evaluation revealed lower volumetric changes for BIO and BCR, with BCR showing volume increase.
Conclusions:
- In vitro immersion solutions affect the evaluation of bioceramic volumetric change.
- Bioceramic materials demonstrate greater volumetric stability when assessed via an in vivo method.
- The in vivo subcutaneous rat model offers a relevant alternative for evaluating bioceramic cement properties, mirroring clinical behavior.
