Bioactive Carbon@CeO₂ Composites as Efficient Antioxidants with Antiamyloid and Radioprotective Potentials

Area of Science:

• Materials Science
• Nanotechnology
• Biomedical Engineering

Background:

• Composites of carbon particles (CPs) and cerium dioxide nanoparticles (CeO2 NPs) offer combined sorption and antioxidant properties for biomedical uses.
• Understanding the relationship between component ratios, physicochemical properties, and biofunctionality is essential for developing these composites.

Purpose of the Study:

• To fabricate C@CeO2 composites with varying molar ratios.
• To investigate how composite parameters influence their bioactivity.

Main Methods:

• Fabrication of C@CeO2 composites using different molar ratios.
• Characterization using X-ray diffraction (XRD), X-ray photoelectron spectroscopy, and electron microscopy.
• Assessment of adsorption potential, stability in aqueous suspension, and various bioactivities.

Main Results:

• C@CeO2 composites were successfully synthesized with highly dispersed CeO2 NPs (4-6 nm) on amorphous CPs.
• CeO2 NP presence reduced carbon's adsorption potential in a dose-dependent manner.
• Redox interactions between carbon and CeO2 altered surface chemistry, enhancing composite stability and bioactivity.

Conclusions:

• The ratio of carbon to cerium dioxide significantly impacts the physicochemical properties and biofunctionality of C@CeO2 composites.
• C@CeO2 composites demonstrate superior pseudomimetic, antiamyloid, and radioprotective activities compared to bare carbon or CeO2.
• These findings highlight the potential of C@CeO2 composites for advanced biomedical applications.