Oxacillinase-484-Producing Enterobacterales, France, 2018-2023
These videos have been matched automatically. Contact us if they are not relevant.
These videos have been matched automatically. Contact us if they are not relevant.
View abstract on PubMed
Summary
This summary is machine-generated.Oxacillinase-484-producing Enterobacterales, particularly Escherichia coli strains ST410 and ST1722, have emerged in France. The blaOXA-484 gene is primarily located on IncX3 plasmids, often with insertion sequences IS3000 and ISKpn19.
Area Of Science
- Microbiology
- Genomics
- Molecular Biology
Background
- Enterobacterales are a significant group of bacteria, some of which can cause serious infections.
- The emergence of antibiotic resistance, such as that conferred by oxacillinase genes, is a major global health concern.
- Oxacillinase-484 (OXA-484) is a carbapenemase that confers resistance to certain antibiotics.
Purpose Of The Study
- To investigate the emergence and genetic characteristics of oxacillinase-484-producing Enterobacterales in France.
- To identify predominant bacterial strains and their associated genetic elements.
- To understand the plasmid-mediated dissemination of the blaOXA-484 gene.
Main Methods
- Genomic analysis of Enterobacterales isolates collected between 2012 and 2023.
- Sequence typing to identify bacterial strains.
- Plasmid analysis to determine the genetic context of the blaOXA-484 gene.
Main Results
- Two predominant sequence types (STs) of Escherichia coli were identified: ST410 and ST1722.
- The blaOXA-484 gene was predominantly found on IncX3-type plasmids.
- Genetic elements including insertion sequences IS3000 and ISKpn19 were associated with the blaOXA-484-carrying plasmids.
Conclusions
- The study highlights the emergence of specific OXA-484-producing E. coli strains in France.
- The IncX3 plasmid appears to be a significant vehicle for the dissemination of the blaOXA-484 gene.
- Understanding the genetic context is crucial for tracking and controlling the spread of antibiotic resistance.
These videos have been matched automatically. Contact us if they are not relevant.
These videos have been matched automatically. Contact us if they are not relevant.
